Bailey D N
Am J Clin Pathol. 1979 Nov;72(5):795-9. doi: 10.1093/ajcp/72.5.795.
Phencyclidine concentrations were measured in the plasmas of 22 patients with nonfatal phencyclidine intoxication using gas-liquid chromatography with a nitrogen detector. Concentrations found ranged from less than 10 to 812 micrograms/l, and except for the systolic blood pressure (r = 0.60, P less than 0.05), showed no significant correlation with the physical findings. The most common physical findings were combativeness-agitation (64%), depressed level of consciousness (50%), hypertension (43%), moiosis (43%), and tachycardia (43%). Phencyclidine concentrations measured in the erythrocytes of seven of the patients were generally higher than concentrations in the corresponding plasmas (erythrocyte:plasma concentration ratios ranged from 3.1 to 37.9), suggesting that the binding of phencyclidine to plasma proteins is low. Erythrocytic concentrations also showed no significant correlation with either the physical findings or the plasma concentrations of phencyclidine. For 15 unselected urines the concentrations of phencyclidine showed no significant correlation with urinary pH.
使用带有氮检测器的气液色谱法，对22例非致死性苯环利定中毒患者的血浆中的苯环利定浓度进行了测量。测得的浓度范围为低于10至812微克/升，除收缩压外（r = 0.60，P < 0.05），与体格检查结果无显著相关性。最常见的体格检查结果为好斗-激动（64%）、意识水平降低（50%）、高血压（43%）、瞳孔缩小（43%）和心动过速（43%）。对7例患者红细胞中的苯环利定浓度进行测量，其浓度通常高于相应血浆中的浓度（红细胞：血浆浓度比范围为3.1至37.9），这表明苯环利定与血浆蛋白的结合率较低。红细胞浓度与体格检查结果或血浆中苯环利定浓度也均无显著相关性。对于15份随机选取的尿液，苯环利定浓度与尿液pH值无显著相关性。
