胆汁盐的比较研究。来自巨骨舌鱼（居维叶）（骨舌鱼科）的一种新型胆汁盐。
Comparative studies of bile salts. A new type of bile salt from Arapaima gigas (Cuvier) (family Osteoglossidae).
作者信息
Haslewood G A, Tökés L
出版信息
Biochem J. 1972 Mar;126(5):1161-70. doi: 10.1042/bj1261161.
Abstract
- Arapaima gigas bile salts were hydrolysed by alkali or cleaved with dioxan-trichloroacetic acid to give cholic acid, arapaimic acid, arapaimol-A and arapaimol-B. 2. I.r., n.m.r. and mass spectroscopy and alpha measurements indicated that arapaimic acid and arapaimol-A and -B are respectively 2alpha,3alpha,7alpha,12alpha-tetrahydroxy-5beta,25in-cholestan-26-oic acid, 5beta,25R-cholestane-2beta,3alpha,7alpha,12alpha,26-pentol and 5beta-cholestane-2beta,3alpha,7alpha,12alpha,26,27-hexol. 3. Partial synthesis of 2beta,3alpha,7alpha,12alpha-tetrahydroxy-5alpha- and -5beta-cholan-24-oic acid and their spectral examination fully confirmed these conclusions. 4. A. gigas bile salts show primitive features in that they comprise alcohol sulphates and a C(27) acid; they are also specialized in showing 2beta-hydroxylation.
摘要
- 巨骨舌鱼胆汁盐用碱水解或用二氧六环 - 三氯乙酸裂解，得到胆酸、巨骨舌鱼酸、巨骨舌醇 - A和巨骨舌醇 - B。2. 红外光谱、核磁共振光谱、质谱以及比旋光度测量表明，巨骨舌鱼酸、巨骨舌醇 - A和 - B分别是2α,3α,7α,12α - 四羟基 - 5β,25 - 胆甾烷 - 26 - 羧酸、5β,25R - 胆甾烷 - 2β,3α,7α,12α,26 - 戊醇和5β - 胆甾烷 - 2β,3α,7α,12α,26,27 - 己醇。3. 2β,3α,7α,12α - 四羟基 - 5α - 和 - 5β - 胆烷 - 24 - 羧酸的部分合成及其光谱检测充分证实了这些结论。4. 巨骨舌鱼胆汁盐具有原始特征，因为它们包含醇硫酸盐和一种C(27)酸；它们还具有特殊之处，表现出2β - 羟基化。
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