无菌家禽和猪的胆汁盐。
Bile salts of germ-free domestic fowl and pigs.
作者信息
Haslewood G A
出版信息
Biochem J. 1971 Jun;123(1):15-8. doi: 10.1042/bj1230015.
Abstract
- The bile of germ-free domestic fowl contains taurine conjugates of 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid (chenodeoxycholic acid), 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid (cholic acid) and its 5alpha-epimer (allocholic acid): that of germ-free pigs contains glycine and taurine conjugates of chenodeoxycholic acid, 3alpha,6alpha-dihydroxy-5beta-cholan-24-oic acid (hyodeoxycholic acid), 3alpha,6alpha,7alpha-trihydroxy-5beta-cholan-24-oic acid (hyocholic acid) and (probably) cholic acid. Keto acids were not found. 2. Allocholic acid and hyodeoxycholic acid are thus proved to be primary bile acids in intact animals. 3. The evolutionary and biochemical implications of these findings are briefly considered.
摘要
- 无菌家禽的胆汁含有3α,7α - 二羟基 - 5β - 胆烷 - 24 - 酸（鹅去氧胆酸）、3α,7α,12α - 三羟基 - 5β - 胆烷 - 24 - 酸（胆酸）及其5α - 差向异构体（别胆酸）的牛磺酸共轭物：无菌猪的胆汁含有鹅去氧胆酸、3α,6α - 二羟基 - 5β - 胆烷 - 24 - 酸（猪去氧胆酸）、3α,6α,7α - 三羟基 - 5β - 胆烷 - 24 - 酸（猪胆酸）以及（可能）胆酸的甘氨酸和牛磺酸共轭物。未发现酮酸。2. 因此，别胆酸和猪去氧胆酸被证明是完整动物体内的初级胆汁酸。3. 简要考虑了这些发现的进化和生化意义。
相似文献
1
Bile salts of germ-free domestic fowl and pigs.无菌家禽和猪的胆汁盐。
Biochem J. 1971 Jun;123(1):15-8. doi: 10.1042/bj1230015.
2
Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat.半合成胆汁酸 FXR 和 TGR5 激动剂：在大鼠中的理化性质、药代动力学和代谢。
J Pharmacol Exp Ther. 2014 Jul;350(1):56-68. doi: 10.1124/jpet.114.214650. Epub 2014 May 1.
3
Bile acids in porcine fetal bile.猪胎儿胆汁中的胆汁酸。
Biol Pharm Bull. 2000 Oct;23(10):1143-6. doi: 10.1248/bpb.23.1143.
4
Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic acid.鸊鷉科鸟类中的胆汁酸：牛磺酸结合的（24R,25R）-3α,7α,24-三羟基-5β-胆甾烷-27-酸和 3α,7α-二羟基-5β-胆甾烷-27-酸的两个差向异构体（25R 和 25S）。
Steroids. 2011 Sep-Oct;76(10-11):1126-35. doi: 10.1016/j.steroids.2011.04.017. Epub 2011 May 11.
5
Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.鉴定参与胆酸和鹅去氧胆酸生物转化的人肝细胞色素P450酶。
Drug Metab Dispos. 2008 Oct;36(10):1983-91. doi: 10.1124/dmd.108.022194. Epub 2008 Jun 26.
6
Metabolism of (24R and 24S)-27-nor-24-methyl-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acids and 27-nor-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid in guinea pigs.豚鼠体内（24R和24S）-27-降-24-甲基-3α,7α-二羟基-5β-胆甾烷-26-酸及27-降-3α,7α-二羟基-5β-胆甾烷-26-酸的代谢
Steroids. 1978 Dec;32(5):659-67. doi: 10.1016/0039-128x(78)90076-4.
7
Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man.胆汁淤积时血清和尿液中胆汁酸的鉴定。人类胆汁酸6α-羟基化的证据。
Biochem J. 1976 Feb 15;154(2):507-16. doi: 10.1042/bj1540507.
8
Rapid identification of bile acids in snake bile using ultrahigh-performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.使用超高效液相色谱-电喷雾电离四极杆飞行时间串联质谱法快速鉴定蛇胆中的胆汁酸
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 15;1036-1037:157-169. doi: 10.1016/j.jchromb.2016.10.011. Epub 2016 Oct 11.
9
Chemical Synthesis of Rare Natural Bile Acids: 11α-Hydroxy Derivatives of Lithocholic and Chenodeoxycholic Acids.稀有天然胆汁酸的化学合成：石胆酸和鹅去氧胆酸的11α-羟基衍生物
Lipids. 2018 Apr;53(4):403-411. doi: 10.1002/lipd.12013. Epub 2018 Mar 9.
10
Synthesis of coenzyme A esters of 3alpha,7alpha,12alpha-trihydroxy- and 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oic acids for the study of beta-oxidation in bile acid biosynthesis.合成3α,7α,12α-三羟基-和3α,7α-二羟基-24-氧代-5β-胆甾烷-26-酸的辅酶A酯用于胆汁酸生物合成中β-氧化的研究。
Steroids. 2001 Jun;66(6):499-504. doi: 10.1016/s0039-128x(00)00209-9.
引用本文的文献
1
In vivo tracking of grape marc biomarkers, bioconversion, metabolic tracers, and microbiota modulation in swine fed a polyphenol-rich extract diet.在喂食富含多酚提取物日粮的猪体内追踪葡萄渣生物标志物、生物转化、代谢示踪剂和微生物群调节情况。
PLoS One. 2025 Jun 10;20(6):e0325079. doi: 10.1371/journal.pone.0325079. eCollection 2025.
2
Birth of a pathway for sulfur metabolism in early amniote evolution.早期羊膜动物进化中硫代谢途径的产生。
Nat Ecol Evol. 2020 Sep;4(9):1239-1246. doi: 10.1038/s41559-020-1232-4. Epub 2020 Jun 29.
3
Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis.PXR 和 CAR 的药理学激活下调了不同的胆汁酸代谢肠道细菌，并改变了胆汁酸稳态。
Toxicol Sci. 2019 Mar 1;168(1):40-60. doi: 10.1093/toxsci/kfy271.
4
Fecal Hyodeoxycholic Acid Is Correlated With Tylosin-Induced Microbiome Changes in Growing Pigs.粪便猪去氧胆酸与泰乐菌素诱导的生长猪微生物群变化相关。
Front Vet Sci. 2018 Aug 28;5:196. doi: 10.3389/fvets.2018.00196. eCollection 2018.
5
Bile salt hydrolases: Structure and function, substrate preference, and inhibitor development.胆汁盐水解酶：结构与功能、底物偏好及抑制剂开发。
Protein Sci. 2018 Oct;27(10):1742-1754. doi: 10.1002/pro.3484. Epub 2018 Sep 24.
6
Therapeutic uses of animal biles in traditional Chinese medicine: an ethnopharmacological, biophysical chemical and medicinal review.动物胆汁在传统中医中的治疗用途：民族药理学、生物物理化学及医学综述
World J Gastroenterol. 2014 Aug 7;20(29):9952-75. doi: 10.3748/wjg.v20.i29.9952.
7
In vitro appraisal of the probiotic value of intestinal lactobacilli.肠道乳杆菌益生菌价值的体外评价。
World J Microbiol Biotechnol. 1991 Nov;7(6):587-92. doi: 10.1007/BF00452836.
8
Comparative studies of bile salts. A new type of bile salt from Arapaima gigas (Cuvier) (family Osteoglossidae).胆汁盐的比较研究。来自巨骨舌鱼（居维叶）（骨舌鱼科）的一种新型胆汁盐。
Biochem J. 1972 Mar;126(5):1161-70. doi: 10.1042/bj1261161.
9
A more detailed study of bile salt evolution, including techniques for small-scale identification and their application to amphibian biles.对胆汁盐演变的更详细研究，包括小规模鉴定技术及其在两栖动物胆汁中的应用。
Biochem J. 1974 Aug;141(2):485-94. doi: 10.1042/bj1410485.
10
Subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain, feed efficiency, and bacterial cholyltaurine hydrolase activity.家禽饲料中抗生素的亚治疗水平及其对体重增加、饲料效率和细菌胆酰牛磺酸水解酶活性的影响。
Appl Environ Microbiol. 1987 Feb;53(2):331-6. doi: 10.1128/aem.53.2.331-336.1987.
本文引用的文献
1
Detection of steroids in paper chromatography.纸色谱法中类固醇的检测
Arch Biochem Biophys. 1952 Feb;35(2):346-51. doi: 10.1016/s0003-9861(52)80015-3.
2
3
THIN-LAYER CHROMATOGRAPHY OF BILE ACIDS.胆汁酸的薄层色谱法
J Lipid Res. 1963 Jan;4:11-6.
4
THIN-LAYER CHROMATOGRAPHY OF BILE ACIDS WITH SPECIAL REFERENCE TO SEPARATION OF KETO BILE ACIDS.胆汁酸的薄层色谱法，特别涉及酮胆汁酸的分离
J Biochem. 1963 Sep;54:283-6. doi: 10.1093/oxfordjournals.jbchem.a127785.
5
Comparative studiesof 'bile salts'. 15. The natural occurrence and preparation of allocholic acid.“胆汁盐”的比较研究。15. 别胆酸的天然存在与制备。
Biochem J. 1962 Oct;85(1):236-42. doi: 10.1042/bj0850236.
6
Cholesterol-4-C 14 and bile acids in the guinea pig.豚鼠体内的胆固醇-4-C 14与胆汁酸
Proc Soc Exp Biol Med. 1961 Jan;106:177-80. doi: 10.3181/00379727-106-26277.
7
Comparative studies of bile salts. 9. The isolation and chemistry of hyocholic acid.胆汁盐的比较研究。9. 猪去氧胆酸的分离与化学性质。
Biochem J. 1956 Apr;62(4):637-45. doi: 10.1042/bj0620637.
8
The formation of lithocholic acid, chenodeoxycholic acid and alpha- and beta-muricholic acids from cholesterol incubated with rat-liver mitochondria.胆固醇与大鼠肝脏线粒体一起孵育生成石胆酸、鹅去氧胆酸以及α-和β-鼠胆酸。
Biochem J. 1967 May;103(2):472-9. doi: 10.1042/bj1030472.
9
Bile acid composition of bile from germ-free rabbits.无菌兔胆汁的胆汁酸成分
Biochim Biophys Acta. 1969 Jan 21;176(1):204-7. doi: 10.1016/0005-2760(69)90092-7.
Zotero 插件