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无菌家禽和猪的胆汁盐。

Bile salts of germ-free domestic fowl and pigs.

作者信息

Haslewood G A

出版信息

Biochem J. 1971 Jun;123(1):15-8. doi: 10.1042/bj1230015.

DOI:10.1042/bj1230015
PMID:5128663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1176895/
Abstract
  1. The bile of germ-free domestic fowl contains taurine conjugates of 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid (chenodeoxycholic acid), 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid (cholic acid) and its 5alpha-epimer (allocholic acid): that of germ-free pigs contains glycine and taurine conjugates of chenodeoxycholic acid, 3alpha,6alpha-dihydroxy-5beta-cholan-24-oic acid (hyodeoxycholic acid), 3alpha,6alpha,7alpha-trihydroxy-5beta-cholan-24-oic acid (hyocholic acid) and (probably) cholic acid. Keto acids were not found. 2. Allocholic acid and hyodeoxycholic acid are thus proved to be primary bile acids in intact animals. 3. The evolutionary and biochemical implications of these findings are briefly considered.
摘要
  1. 无菌家禽的胆汁含有3α,7α - 二羟基 - 5β - 胆烷 - 24 - 酸（鹅去氧胆酸）、3α,7α,12α - 三羟基 - 5β - 胆烷 - 24 - 酸（胆酸）及其5α - 差向异构体（别胆酸）的牛磺酸共轭物：无菌猪的胆汁含有鹅去氧胆酸、3α,6α - 二羟基 - 5β - 胆烷 - 24 - 酸（猪去氧胆酸）、3α,6α,7α - 三羟基 - 5β - 胆烷 - 24 - 酸（猪胆酸）以及（可能）胆酸的甘氨酸和牛磺酸共轭物。未发现酮酸。2. 因此，别胆酸和猪去氧胆酸被证明是完整动物体内的初级胆汁酸。3. 简要考虑了这些发现的进化和生化意义。

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本文引用的文献

1
Detection of steroids in paper chromatography.纸色谱法中类固醇的检测
Arch Biochem Biophys. 1952 Feb;35(2):346-51. doi: 10.1016/s0003-9861(52)80015-3.
2
Bile acids and steroids. 90. The stereo-chemical course of the reduction of the cholesterol double bond in bile acid formation.胆汁酸与类固醇。90. 胆汁酸形成过程中胆固醇双键还原的立体化学过程。
J Biol Chem. 1959 Nov;234:2852-6.
3
THIN-LAYER CHROMATOGRAPHY OF BILE ACIDS.胆汁酸的薄层色谱法
J Lipid Res. 1963 Jan;4:11-6.
4
THIN-LAYER CHROMATOGRAPHY OF BILE ACIDS WITH SPECIAL REFERENCE TO SEPARATION OF KETO BILE ACIDS.胆汁酸的薄层色谱法，特别涉及酮胆汁酸的分离
J Biochem. 1963 Sep;54:283-6. doi: 10.1093/oxfordjournals.jbchem.a127785.
5
Comparative studiesof 'bile salts'. 15. The natural occurrence and preparation of allocholic acid.“胆汁盐”的比较研究。15. 别胆酸的天然存在与制备。
Biochem J. 1962 Oct;85(1):236-42. doi: 10.1042/bj0850236.
6
Cholesterol-4-C 14 and bile acids in the guinea pig.豚鼠体内的胆固醇-4-C 14与胆汁酸
Proc Soc Exp Biol Med. 1961 Jan;106:177-80. doi: 10.3181/00379727-106-26277.
7
Comparative studies of bile salts. 9. The isolation and chemistry of hyocholic acid.胆汁盐的比较研究。9. 猪去氧胆酸的分离与化学性质。
Biochem J. 1956 Apr;62(4):637-45. doi: 10.1042/bj0620637.
8
The formation of lithocholic acid, chenodeoxycholic acid and alpha- and beta-muricholic acids from cholesterol incubated with rat-liver mitochondria.胆固醇与大鼠肝脏线粒体一起孵育生成石胆酸、鹅去氧胆酸以及α-和β-鼠胆酸。
Biochem J. 1967 May;103(2):472-9. doi: 10.1042/bj1030472.
9
Bile acid composition of bile from germ-free rabbits.无菌兔胆汁的胆汁酸成分
Biochim Biophys Acta. 1969 Jan 21;176(1):204-7. doi: 10.1016/0005-2760(69)90092-7.
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J Lipid Res. 1968 Mar;9(2):237-43.