Spooner R L, Oliver R A, Sales D I, McCoubrey C M, Millar P, Morgan A G, Amorena B, Bailey E, Bernoco D, Brandon M, Bull R W, Caldwell J, Cwik S, van Dam R H, Dodd J, Gahne B, Grosclaude F, Hall J G, Hines H, Leveziel H, Newman M J, Stear M J, Stone W H, Vaiman M
Anim Blood Groups Biochem Genet. 1979;10(2):63-86. doi: 10.1111/j.1365-2052.1979.tb01009.x.
The results and agreements of the 1 international BoLA workshop, held in Edinburgh, Scotland in August 1978, are reported. Most of these concern the results from a comparison test of 249 alloantisera to bovine lymphocytes, the antisera being contributed by 9 laboratories. These sera were compared directly in Edinburgh on a panel of lymphocytes from 130 cattle of 21 breeds. In the microlymphocytotoxicity test used 75% of the sera reacted. Sixty eight of these sera were grouped into clusters according to their reaction patterns against the lymphocyte panel. Eleven of these clusters were clearly defined and were given workshop BoLA designations. In addition 22 sera were assigned to subgroups of the agreed clusters. There was no evidence that the method of production of the sera had any effect on their specificity. Although genetic data was not available, the phenotypes of the test panel of lymphocytes are consistent with the clusters detecting antigens controlled by multiple alleles at a single autosomal locus. It was agreed to name the genetic region where this putative locus is located BoLA (bovine lymphocyte antigen).
本文报道了1978年8月在苏格兰爱丁堡举行的第一届国际牛白细胞抗原（BoLA）研讨会的结果和达成的共识。其中大部分内容涉及对249份牛淋巴细胞同种抗血清的比较试验结果，这些抗血清由9个实验室提供。这些血清在爱丁堡直接用来自21个品种的130头牛的淋巴细胞进行了比较。在所用的微量淋巴细胞毒性试验中，75%的血清发生了反应。根据这些血清对淋巴细胞组的反应模式，其中68份血清被分成了不同的簇。其中11个簇得到了明确界定，并被赋予了研讨会BoLA命名。此外，22份血清被归入了已达成共识的簇的亚组。没有证据表明血清的制备方法对其特异性有任何影响。尽管当时没有遗传数据，但淋巴细胞测试组的表型与这些簇检测由单个常染色体位点上的多个等位基因控制的抗原是一致的。会议商定，将这个假定基因座所在的遗传区域命名为BoLA（牛淋巴细胞抗原）。
