Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège (ULg), 4000, Liège, Belgium.
Viruses. 2011 Jul;3(7):1210-48. doi: 10.3390/v3071210. Epub 2011 Jul 19.
Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important economic losses. A series of attempts were developed to reduce prevalence, chiefly by eradication of infected cattle, segregation of BLV-free animals and vaccination. Although having been instrumental in regions such as the EU, these strategies were unsuccessful elsewhere mainly due to economic costs, management restrictions and lack of an efficient vaccine. This review, which summarizes the different attempts previously developed to decrease seroprevalence of BLV, may be informative for management of HTLV-1 infection. We also propose a new approach based on competitive infection with virus deletants aiming at reducing proviral loads.
牛白血病病毒（BLV）是一种与人类 T 淋巴细胞白血病病毒 1 型（HTLV-1）密切相关的逆转录病毒。BLV 是全球范围内的一个主要动物健康问题，造成了重大的经济损失。人们已经开发了一系列尝试来降低其流行率，主要通过消除感染的牛、分离 BLV 阴性动物和接种疫苗来实现。尽管这些策略在欧盟等地区发挥了重要作用，但在其他地方由于经济成本、管理限制和缺乏有效的疫苗而未能成功。本文总结了先前为降低 BLV 血清阳性率而开发的不同尝试，这可能对 HTLV-1 感染的管理具有参考价值。我们还提出了一种新的方法，基于与缺失病毒的竞争感染，旨在降低前病毒载量。
