有功能胆囊的胆结石患者的胆汁盐代谢
Bile salt metabolism in patients with gallstones in functioning gallbladders.
作者信息
Pomare E W, Heaton K W
出版信息
Gut. 1973 Nov;14(11):885-90. doi: 10.1136/gut.14.11.885.
Abstract
Isotopic bile salt studies were carried out in eight middle-aged women with radiolucent galstones in functioning gallbladders and in 10 matched controls. In the gallstone patients the size of the bile salt pool was reduced by 37% to 1.79 g, but there was considerable overlap with the normal subjects. The cholate and chenodeoxycholate pools were reduced, but the deoxycholate pool was normal in size. There were changes in bile salt metabolism which resembled those found after cholecystectomy but were less marked. This suggests that in gallstone disease the storage capacity of the gallbladder is impaired. This may contribute to the small bile salt pool, but it is unlikely to be the sole or even the major cause.
摘要
对8名胆囊功能正常但有透X线胆结石的中年女性以及10名匹配的对照者进行了同位素胆盐研究。胆结石患者的胆盐池大小减少了37%，降至1.79克，但与正常受试者有相当大的重叠。胆酸和鹅去氧胆酸池减少，但脱氧胆酸池大小正常。胆盐代谢发生了变化，类似于胆囊切除术后发现的变化，但程度较轻。这表明在胆结石疾病中，胆囊的储存能力受损。这可能导致胆盐池较小，但不太可能是唯一甚至主要原因。
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本文引用的文献
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