肾动脉狭窄伴严重高血压。一例罕见病例，对病变发生前后的肾素-血管紧张素系统进行了详细评估。
Renal artery stenosis with severe hypertension. A rare case with detailed assessment of renin-angiotensin system before and after development of lesion.
作者信息
Mackay A, Cumming A M
出版信息
Br Heart J. 1979 Oct;42(4):480-2. doi: 10.1136/hrt.42.4.480.
Abstract
The rare opportunity arose to assess in detail the renin-angiotensin system before and after the development of a renal artery stenosis with severe hypertension. Peripheral plasma concentrations of renin, angiotensin II, and aldosterone were known to be normal before the development of renal artery stenosis, and there were no lateralising features on renal vein sampling. Acute hypertension associated with very high peripheral plasma concentrations of renin and angiotensin II, and with pronounced lateralisation on renal vein sampling followed the development of acute unilateral renal artery stenosis. These measurements all returned to normal after nephrectomy, conforming with the pattern of changes previously established only in experimental animals.
摘要
出现了一个难得的机会，可以在肾动脉狭窄伴严重高血压发生之前和之后详细评估肾素-血管紧张素系统。已知在肾动脉狭窄发生之前，外周血中肾素、血管紧张素II和醛固酮的浓度是正常的，肾静脉采样也没有定位特征。急性单侧肾动脉狭窄发生后，出现了与外周血中肾素和血管紧张素II浓度非常高相关的急性高血压，以及肾静脉采样时明显的定位特征。肾切除术后，这些测量值均恢复正常，这与之前仅在实验动物中确立的变化模式相符。
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