苯妥英及其对羟基化代谢产物在新生儿体内经胎盘转运的动力学
Kinetics of placentally transferred phenytoin and its p-hydroxylated metabolites in newborn infants.
作者信息
Rane A, Hoppel C, Höjer B
出版信息
Br J Clin Pharmacol. 1979 Nov;8(5):465-8. doi: 10.1111/j.1365-2125.1979.tb01027.x.
Abstract
1 The kinetics of phenytoin and its main metabolites, unconjugated and conjugated 4-hydroxy-phenytoin were studied in newborn infants of epileptic mothers that were treated with phenytoin during the pregnancy. 2 In two of the infants phenytoin was eliminated by an apparent zero-order process followed by an apparent first-order process. In the other two infants the mode of elimination could not be characterized. 3 The decline of plasma conjugated 4-hydroxy-phenytoin was parallel to that of phenytoin. In contrast, the plasma concentration of unconjugated 4-hydroxy-phenytoin remained grossly constant during the first 3 to 4 days.
摘要
- 对孕期接受苯妥英治疗的癫痫母亲所生新生儿体内苯妥英及其主要代谢产物（未结合和结合型4-羟基苯妥英）的动力学进行了研究。2. 其中两名婴儿体内苯妥英先通过明显的零级过程消除，随后是明显的一级过程。另外两名婴儿的消除模式无法确定。3. 血浆结合型4-羟基苯妥英的下降与苯妥英平行。相比之下，未结合型4-羟基苯妥英的血浆浓度在最初3至4天内基本保持恒定。
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Kinetics of placentally transferred phenytoin and its p-hydroxylated metabolites in newborn infants.苯妥英及其对羟基化代谢产物在新生儿体内经胎盘转运的动力学
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3
[The significance of cumulation and elimination for the determination of Phenytoin (diphenylhydantoin)].
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4
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5
Inhibition of diphenylhydantoin elimination by its major metabolite.
Res Commun Chem Pathol Pharmacol. 1972 Sep;4(2):297-306.
6
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Clin Pharmacol Ther. 1974 Jan;15(1):39-45. doi: 10.1002/cpt197415139.
7
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