新生儿中苯妥英代谢物的尿排泄情况。
Urinary excretion of diphenylhydantoin metabolites in newborn infants.
作者信息
Rane A
出版信息
J Pediatr. 1974 Oct;85(4):543-5. doi: 10.1016/s0022-3476(74)80466-x.
PMID:4475101
Abstract
The plasma half-life of diphenylhydantoin newborn infants of epileptic mothers, treated with this drug, is in the same range as the plasma half-life in adults. The urinary excretion of diphenylydantoin and its main metabolites has been investigated in six newborn infants. The results show that the rapid plasma disappearance of diphenylhydantoin is due to rapid metabolism of the drug.
摘要
接受这种药物治疗的癫痫母亲所生新生儿的苯妥英钠血浆半衰期与成年人的血浆半衰期处于同一范围。已对六名新生儿的苯妥英钠及其主要代谢产物的尿排泄情况进行了研究。结果表明，苯妥英钠在血浆中快速消失是由于该药的快速代谢。
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