丙咪嗪和多塞平对正常志愿者唾液分泌率的比较效应。
Comparative effects of imipramine and dothiepin on salivary rate in normal volunteers.
作者信息
Sheth U K, Paul T, Desai N K, Pispati P K
出版信息
Br J Clin Pharmacol. 1979 Nov;8(5):475-8. doi: 10.1111/j.1365-2125.1979.tb01029.x.
1 Imipramine induced significant reduction in salivary rate compared to placebo in a cross-over, double-blind study of twelve normal volunteers. In contrast, there was no significant difference between the reduction in salivary rate induced by dothiepin and placebo. 2 Comparison of salivary rates showed no significant difference between the drugs in the initial and cross-over treatment periods. However, pooled observations from the initial and cross-over treatment periods indicated that imipramine produced a significantly greater reduction in salivary rate than dothiepin. 3 The results suggest that dothiepin would cause far less dryness of mouth compared to imipramine. This feature might ensure greater therapeutic compliance.
- 在一项针对12名正常志愿者的交叉双盲研究中，与安慰剂相比，丙咪嗪可显著降低唾液分泌率。相比之下，多塞平所致唾液分泌率降低与安慰剂之间无显著差异。2. 唾液分泌率比较显示，在初始治疗期和交叉治疗期，各药物之间无显著差异。然而，初始治疗期和交叉治疗期的汇总观察结果表明，丙咪嗪导致的唾液分泌率降低幅度显著大于多塞平。3. 结果表明，与丙咪嗪相比，多塞平引起的口干程度要轻得多。这一特性可能会确保更高的治疗依从性。
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