Caruso I, Sarzi Puttini P C, Boccassini L, Santandrea S, Locati M, Volpato R, Montrone F, Benvenuti C, Beretta A
J Int Med Res. 1987 May-Jun;15(3):154-9. doi: 10.1177/030006058701500305.
A double-blind study comparing the efficacy and tolerability of dothiepin with that of placebo in the treatment of primary fibromyalgia syndrome was carried out. Dothiepin was shown to improve significantly the condition of patients with primary fibromyalgia syndrome and there was a significant difference between dothiepin and placebo in all the clinical variables measured. Only mild and transient side-effects were reported. Further controlled studies are required to define the effects of dothiepin on fibromyalgia.
开展了一项双盲研究，比较多塞平与安慰剂治疗原发性纤维肌痛综合征的疗效和耐受性。结果显示，多塞平能显著改善原发性纤维肌痛综合征患者的病情，在所有测量的临床变量中，多塞平与安慰剂之间存在显著差异。仅报告了轻微和短暂的副作用。需要进一步的对照研究来确定多塞平对纤维肌痛的影响。
