Watras J, Wideł M, Suwiński J
Br J Cancer. 1979 Sep;40(3):354-9. doi: 10.1038/bjc.1979.188.
The transplantable Guerin epithelioma in Wistar rats was used to test the in vivo effectiveness of 1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole (P1) as a tumour-cell radiosensitizer after its oral administration at relatively low doses. The radiosensitizing ability of P1 was compared with that of metronidazole. The results indicate that P1 is less toxic than metronidazole, and greater concentrations of P1 in blood and tumour tissues are obtained for the same administered dose of the compounds. The radiosensitizing ability of P1, determined from tumour-regression rates and local-control percentage at 130 days, was higher than that of metronidazole.
将可移植的Wistar大鼠格伦上皮瘤用于测试1-(2-羟基-3-甲氧基丙基)-2-甲基-4-硝基咪唑（P1）在相对低剂量口服给药后作为肿瘤细胞放射增敏剂的体内有效性。将P1的放射增敏能力与甲硝唑的进行比较。结果表明，P1的毒性低于甲硝唑，并且在相同化合物给药剂量下，血液和肿瘤组织中P1的浓度更高。根据130天时的肿瘤退缩率和局部控制率确定，P1的放射增敏能力高于甲硝唑。
