局部应用氯霉素眼药水的全身吸收。
Systemic absorption of topically applied chloramphenicol eyedrops.
作者信息
Trope G E, Lawrence J R, Hind V M, Bunney J
出版信息
Br J Ophthalmol. 1979 Oct;63(10):690-1. doi: 10.1136/bjo.63.10.690.
Abstract
Five children under the age of 9 years had topical chloramphenicol drops administered 2-hourly to each eye for 5 to 7 days. Systemic absorption was not detected by 2 sensitive assays for the drug. The hazards of topical chloramphenicol and reports in the current literature are discussed.
摘要
5名9岁以下儿童每只眼睛每隔2小时滴注一次氯霉素眼药水，持续5至7天。通过两种灵敏的药物检测方法均未检测到药物的全身吸收情况。本文讨论了局部使用氯霉素的风险以及当前文献中的相关报道。
相似文献
1
Systemic absorption of topically applied chloramphenicol eyedrops.局部应用氯霉素眼药水的全身吸收。
Br J Ophthalmol. 1979 Oct;63(10):690-1. doi: 10.1136/bjo.63.10.690.
2
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3
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引用本文的文献
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Widespread ocular use of topical chloramphenicol: is there justifiable concern regarding idiosyncratic aplastic anaemia?氯霉素眼药水的广泛眼部使用：对于特异性再生障碍性贫血的担忧是否合理？
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Ocular chloramphenicol and aplastic anaemia. Is there a link?眼部使用氯霉素与再生障碍性贫血。二者有关联吗？
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本文引用的文献
1
BONE-MARROW HYPOPLASIA FOLLOWING USE OF CHLORAMPHENICOL EYE DROPS.
JAMA. 1965 Jan 11;191:136-7. doi: 10.1001/jama.1965.03080020064025.
2
Bone marrow, blood and assay levels following medication of cats with chloramphenicol ophthalmic ointment.
Vet Med Small Anim Clin. 1973 Aug;68(8):895-6 passim.
3
Chloramphenicol in aqueous humor after topical application.局部应用后房水中的氯霉素。
Arch Ophthalmol. 1975 Mar;93(3):184-5. doi: 10.1001/archopht.1975.01010020192004.
4
Quantitative gas-chromatographic flame-ionization method for chloramphenicol in human serum.
Clin Chem. 1977 Feb;23(2 PT. 1):220-2.
5
Ocular penetration of chloramphenicol. Effects of route of administration.
Arch Ophthalmol. 1977 May;95(5):879-82. doi: 10.1001/archopht.1977.04450050157020.
6
Letter: Chloramphenicol eye-drops and marrow aplasia.
Lancet. 1975 Aug 16;2(7929):326-7. doi: 10.1016/s0140-6736(75)92766-x.
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