Patten S B, Love E J
Alberta Heritage Foundation for Medical Research, Department of Community Health Sciences, University of Calgary, Canada.
J Psychiatry Neurosci. 1993 May;18(3):92-102.
Drug-induced depressive disorders are classified in the DSM-III-R as organic mood syndrome, depressed type. The ability of certain drugs to cause depression is of clinical relevance because organic mood syndrome is a component of the differential diagnosis of depressive symptoms. Consequently, psychiatric textbooks often provide different lists of drugs thought to be capable of causing depression. Strong evidence supporting the existence of causal associations is often lacking. There is no specific drug for which there is definitive evidence of a causal association with depressive symptoms or depressive disorders. Nevertheless, for a number of drugs, the evidence is suggestive, although not conclusively, of a causal association. Despite this, rational decisions about the continuation or discontinuation of drugs can often be made. In this paper, the literature is reviewed and guidelines are suggested for the management of patients with depressive symptoms which may be related to drugs.
药物所致的抑郁障碍在《精神疾病诊断与统计手册》第三版修订本（DSM - III - R）中被归类为器质性心境综合征，抑郁型。某些药物引发抑郁的能力具有临床相关性，因为器质性心境综合征是抑郁症状鉴别诊断的一个组成部分。因此，精神科教科书常常列出不同的被认为可能导致抑郁的药物清单。但往往缺乏支持因果关联存在的有力证据。尚无一种特定药物有确凿证据表明与抑郁症状或抑郁障碍存在因果关联。然而，对于多种药物，虽证据并非结论性的，但提示存在因果关联。尽管如此，关于药物的继续使用或停用，通常仍可做出合理决策。本文对相关文献进行综述，并针对可能与药物相关的抑郁症状患者的管理提出指导原则。
