Cabanillas F, Smith T, Bodey G P, Gutterman J U, Freireich E J
Cancer. 1979 Dec;44(6):1983-9. doi: 10.1002/1097-0142(197912)44:6<1983::aid-cncr2820440604>3.0.co;2-4.
The records of 109 patients with non-Hodgkin's lymphoma of nodular pattern were reviewed to determine which factors were associated with a favorable response to therapy and prolonged survival. A logistic regression model was utilized to identify the pertinent variables. Prognostic factors associated with a favorable response were, in order of decreasing importance: treatment with an Adriamycin combination regimen, absence of bulky tumor, and no exposure to prior chemotherapy. Thos associated with prolonged survival were: normal hemoglobin level, treatment with an Adriamycin combination regimen, female sex, and no prior exposure to therapy. Achievement of complete remission in these disorders resulted in a statistically longer duration of survival compared to partial responses or failures. Patients whose complete remission was induced with an Adriamycin-containing regimen and maintained with BCG immunotherapy had a significantly longer complete remission than those who did not receive BCG. Knowledge of these factors can be important in planning and analyzing future therapeutic trials.
回顾了109例结节型非霍奇金淋巴瘤患者的记录，以确定哪些因素与治疗的良好反应和延长生存期相关。采用逻辑回归模型来识别相关变量。与良好反应相关的预后因素按重要性递减顺序排列为：采用阿霉素联合方案治疗、无巨大肿瘤以及未接受过先前的化疗。与延长生存期相关的因素为：血红蛋白水平正常、采用阿霉素联合方案治疗、女性以及未接受过先前的治疗。与部分缓解或治疗失败相比，这些疾病实现完全缓解导致生存期在统计学上更长。采用含阿霉素方案诱导完全缓解并采用卡介苗免疫疗法维持的患者，其完全缓解期明显长于未接受卡介苗治疗的患者。了解这些因素对于规划和分析未来的治疗试验可能很重要。
