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相似文献

1
Age-related changes in human thymus.人类胸腺的年龄相关变化。
Clin Exp Immunol. 1979 Sep;37(3):507-11.
2
Involution of the mammalian thymus, one of the leading regulators of aging.哺乳动物胸腺的退化，衰老的主要调节因素之一。
In Vivo. 1997 Sep-Oct;11(5):421-40.
3
The role of zinc in pre- and postnatal mammalian thymic immunohistogenesis.锌在哺乳动物产前和产后胸腺免疫组织发生中的作用。
In Vivo. 1998 Nov-Dec;12(6):695-722.
4
The human thymus in ageing: histologic involution paralleled by increased mitogen response and by enrichment of OKT3+ lymphocytes.衰老过程中的人类胸腺：组织学退化与丝裂原反应增强及OKT3 +淋巴细胞富集并行。
Immunology. 1983 Dec;50(4):519-28.
5
[An immunological study of changes in the thymus with aging].
Nihon Geka Gakkai Zasshi. 1992 Jul;93(7):757-65.
6
Lymphocyte subpopulations in non-neoplastic thymus from myasthenia gravis patients.重症肌无力患者非肿瘤性胸腺中的淋巴细胞亚群
Clin Exp Immunol. 1980 Jul;41(1):19-24.
7
Epithelial-cell architecture during involution of the human thymus.人类胸腺 involution 过程中的上皮细胞结构。 注：这里“involution”可能需要结合具体语境准确翻译，比如“退化”“ involution”等。
J Pathol. 1987 Jul;152(3):149-55. doi: 10.1002/path.1711520303.
8
[Thymic lymphocyte subpopulations and myasthenia gravis (author's transl)].胸腺淋巴细胞亚群与重症肌无力（作者译）
Nihon Kyobu Shikkan Gakkai Zasshi. 1978 Sep;16(9):672-7.
9
Lymphocyte content in the aging human thymus.
Thymus. 1989;14(4):265-6.
10
Age-related changes in localization of thymosin in the human thymus.人胸腺中胸腺素定位的年龄相关变化。
Thymus. 1982 Jan;4(1):19-29.

引用本文的文献

1
An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases.深入了解T细胞在免疫器官衰老及与年龄相关疾病中的作用和机制。
Sci China Life Sci. 2025 Feb;68(2):328-353. doi: 10.1007/s11427-024-2695-x. Epub 2024 Sep 2.
2
Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system.压力、衰老及其对免疫系统功能、细胞和分子层面的影响。
Age (Dordr). 2014 Jun;36(3):9631. doi: 10.1007/s11357-014-9631-6. Epub 2014 Feb 25.
3
Age Difference in Morphology and Immunohistology inthe Thymus and Spleen in Crl:CD (SD) Rats.Crl:CD（SD）大鼠胸腺和脾脏形态学及免疫组织学的年龄差异
J Toxicol Pathol. 2012 Mar;25(1):55-61. doi: 10.1293/tox.25.55.
4
Indirect demonstration of the lifetime function of human thymus.人类胸腺终生功能的间接证明。
Clin Exp Immunol. 1998 Feb;111(2):450-6. doi: 10.1046/j.1365-2249.1998.00470.x.
5
Involution patterns of the human thymus. I Size of the cortical area as a function of age.人类胸腺的退化模式。I. 皮质区域大小与年龄的关系。
Clin Exp Immunol. 1982 Feb;47(2):497-504.
6
Autoantibodies to a regulatory T cell subset in human ageing.人类衰老过程中针对调节性T细胞亚群的自身抗体。
Clin Exp Immunol. 1981 Aug;45(2):308-15.
7
Effect of thymosin on glucocorticoid receptor activity and glucocorticoid sensitivity of human thymocytes.胸腺素对人胸腺细胞糖皮质激素受体活性及糖皮质激素敏感性的影响。
Clin Exp Immunol. 1984 Feb;55(2):273-80.
8
The human thymus in ageing: histologic involution paralleled by increased mitogen response and by enrichment of OKT3+ lymphocytes.衰老过程中的人类胸腺：组织学退化与丝裂原反应增强及OKT3 +淋巴细胞富集并行。
Immunology. 1983 Dec;50(4):519-28.
9
Altered cellular response to UV irradiation in a patient affected by premature ageing.一名早衰患者对紫外线照射的细胞反应改变。
Hum Genet. 1986 Jul;73(3):189-92. doi: 10.1007/BF00401225.
10
Production of auto-anti-idiotype antibody during the normal immune response. XIV. Evidence for the antigen-independent operation of the idiotype network.正常免疫反应过程中自身抗独特型抗体的产生。十四、独特型网络抗原非依赖性运作的证据。
Immunology. 1989 Jun;67(2):191-6.

本文引用的文献

1
Ontogeny of the human lymphoid system: study of the cytological maturation and the incorporation of tritiated thymidine and uridine in the foetal thymus and lymph node and in the infantile thymus.人类淋巴系统的个体发生：胎儿胸腺和淋巴结以及婴儿胸腺中细胞学成熟及氚标记胸腺嘧啶核苷和尿苷掺入情况的研究
J Cell Physiol. 1972 Oct;80(2):235-42. doi: 10.1002/jcp.1040800210.
2
Rosette formation by human thymocytes.人类胸腺细胞形成玫瑰花结。
Cell Immunol. 1973 Mar;6(3):362-7. doi: 10.1016/0008-8749(73)90036-1.
3
Functional heterogeneity among the T-derived lymphocytes of the mouse. I. Analysis by adult thymectomy.小鼠T衍生淋巴细胞的功能异质性。I. 成年胸腺切除分析。
J Immunol. 1974 Jul;113(1):27-38.
4
Antigen-binding lymphocytes in human fetal thymus.人类胎儿胸腺中的抗原结合淋巴细胞。
Lancet. 1970 Jun 6;1(7658):1199-202. doi: 10.1016/s0140-6736(70)91787-3.
5
Isolation of normal T cells in chronic lymphatic leukaemia.慢性淋巴细胞白血病中正常T细胞的分离
Lancet. 1973 Jan 20;1(7795):126-9. doi: 10.1016/s0140-6736(73)90196-7.
6
Immunoglobulins on the surface of human lymphocytes.人类淋巴细胞表面的免疫球蛋白。
Lancet. 1971 Oct 16;2(7729):850-2. doi: 10.1016/s0140-6736(71)90224-8.
7
Age involution in the normal human adult thymus.正常成人胸腺的年龄性退化
Clin Exp Immunol. 1975 Feb;19(2):261-5.
8
Populations of lymphocytes separated from human thymocytes.从人胸腺细胞中分离出的淋巴细胞群体。
Clin Exp Immunol. 1975 Feb;19(2):251-9.
9
In vitro differentiation of human marrow cells into T lymphocytes by thymic extracts using the rosette technique.采用玫瑰花结技术，利用胸腺提取物将人骨髓细胞体外分化为T淋巴细胞。
Clin Exp Immunol. 1975 Mar;19(3):475-83.
10
Age, thymic involution, and circulating thymic hormone activity.
J Clin Endocrinol Metab. 1978 Jul;47(1):145-50. doi: 10.1210/jcem-47-1-145.

人类胸腺的年龄相关变化。

Age-related changes in human thymus.

作者信息

Singh J, Singh A K

出版信息

Clin Exp Immunol. 1979 Sep;37(3):507-11.

PMID:509782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537774/
Abstract

Thymic biopsies obtained during open heart surgery were examined for age-related involution of the parenchyma and changes in cell surface characteristics. In parallel with the parenchymal atrophy, E-rosette-forming cells continuously decreased with age and were progressively replaced by an increasing proportion of 'null' lymphoid cells. These changes appeared to be independent of each other. The significance of these findings in the context of the host's immune mechanism is discussed.

摘要

对在心脏直视手术期间获取的胸腺活检组织进行检查，以观察实质的年龄相关性退化以及细胞表面特征的变化。与实质萎缩同时，E花环形成细胞随年龄持续减少，并逐渐被比例不断增加的“无标记”淋巴细胞所取代。这些变化似乎相互独立。本文讨论了这些发现在宿主免疫机制背景下的意义。