Jörstad S, Smeby L C, Wideröe T E, Berg K J
Clin Nephrol. 1979 Oct;12(4):168-73.
Human mononuclear phagocytes cultured in vitro were tested after preincubation with uremic plasma dialyzed in vitro and the effects of pre and post hemodialysis plasma were compared with the effect of dialyzates equilibrated with uremic plasma in vivo. Factors in uremic blood plasma inhibiting phagocytosis of Candida albicans could not be removed by means of conventional hemodialysis with cuprophan (CPN) or polyacrylonitrile (PAN) membranes. Hemofiltrates of uremic blood plasma produced by PAN membranes caused a significant inhibition of phagocytes in our test system while CPN hemofiltrates did not.
体外培养的人单核吞噬细胞在与体外透析的尿毒症血浆预孵育后进行测试，并将血液透析前后血浆的作用与在体内与尿毒症血浆平衡的透析液的作用进行比较。尿毒症血浆中抑制白色念珠菌吞噬作用的因素不能通过使用铜仿膜（CPN）或聚丙烯腈（PAN）膜的常规血液透析去除。在我们的测试系统中，由PAN膜产生的尿毒症血浆血液滤过液对吞噬细胞有显著抑制作用，而CPN血液滤过液则没有。
