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中分子物质的毒性:使用选择性滤过人工肾的临床评估

Toxicity of middle molecules: clinical evaluation using a selective filtration artificial kidney.

作者信息

Jörstad S, Smeby L C, Wideröe T E

出版信息

Artif Organs. 1981;4 Suppl:98-103.

PMID:7295103
Abstract

The effect of four uremic patients, treated 4-6 months with a new artificial kidney system aimed to remove molecules between 10,000-40,000 daltons returning substances with mol wt 200-10,000 back to the patients, was compared with the effect of conventional hemodialysis. The patients treated with this system obtained a more stable hemoglobin concentration without blood transfusions. They got an increased mean nerve conduction velocity and their plasma increased in quality as culture medium on human mononuclear phagocytes grown in vitro.

摘要

对4名尿毒症患者使用一种新型人工肾系统进行治疗4至6个月,该系统旨在清除分子量在10,000至40,000道尔顿之间的分子,并将分子量为200至10,000的物质回输给患者,同时将其效果与传统血液透析的效果进行了比较。接受该系统治疗的患者在未输血的情况下获得了更稳定的血红蛋白浓度。他们的平均神经传导速度有所提高,并且其血浆作为体外培养人单核吞噬细胞的培养基,质量有所提升。

相似文献

1
Toxicity of middle molecules: clinical evaluation using a selective filtration artificial kidney.中分子物质的毒性:使用选择性滤过人工肾的临床评估
Artif Organs. 1981;4 Suppl:98-103.
2
Transport of uremic toxins through conventional hemodialysis membranes.尿毒症毒素通过传统血液透析膜的转运。
Clin Nephrol. 1979 Oct;12(4):168-73.
3
Removal of uraemic toxins by haemofiltration with different membranes. The benefit of regenerating haemofiltrate using a newly developed system.使用不同膜进行血液滤过清除尿毒症毒素。利用新开发系统再生血液滤过液的益处。
Proc Eur Dial Transplant Assoc. 1979;16:212-7.
4
Transport of small, middle, and large molecular weight substances in a dual filtration artificial kidney.双滤过人工肾中小分子、中分子和大分子物质的转运
Artif Organs. 1981;4 Suppl:104-9.
5
The effect of hemodialysis on endogenous middle molecules in uremic patients.
Clin Nephrol. 1979 May;11(5):257-66.
6
Problems and solutions for artificial kidney.人工肾的问题与解决方案
Technol Health Care. 2000;8(6):373-9.
7
[Medium-sized molecules and the process of uremic intoxication].[中等大小分子与尿毒症中毒过程]
Pol Tyg Lek. 1976 Jul 5;31(27):1173-6.
8
Plasma middle molecules in asymptomatic and "sick" uremic patients.无症状和“患病”尿毒症患者的血浆中分子物质
Artif Organs. 1981;4 Suppl:137-42.
9
In vitro cytotoxic properties of plasma fractions from uremic patients.尿毒症患者血浆成分的体外细胞毒性特性。
Artif Organs. 1981;4 Suppl:68-70.
10
Concentration of plasma middle molecular weight substances and clinical condition of patients undergoing short-time regular dialysis treatment.
Artif Organs. 1981;4 Suppl:173-6.

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beta 2-Microglobulin amyloidosis. A systemic amyloid disease affecting primarily synovium and bone in long-term dialysis patients.β2微球蛋白淀粉样变性。一种主要影响长期透析患者滑膜和骨骼的全身性淀粉样疾病。
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