赞比亚的热带脾肿大综合征：环氯胍和氯胍的进一步观察及效果
Tropical splenomegaly syndrome in Zambia: further observations and effects of cycloguanil and proguanil.
作者信息
Lowenthal M N, O'Riordan E C, Hutt M S
出版信息
Br Med J. 1971 Feb 20;1(5746):429-32. doi: 10.1136/bmj.1.5746.429.
Abstract
Nineteen Zambian patients with the tropical splenomegaly syndrome and sinusoidal lymphocytosis on liver biopsy were studied. The association of macrobulinaemia with the tropical splenomegaly syndrome has again been confirmed. Sixteen patients were treated with antimalarials-12 with cycloguanil pamoate alone, 3 with cycloguanil and proguanil, and 1 with proguanil alone. Twelve patients were observed for periods of sufficient length for the drug effect to be assessed, and in 11 there was a good response in terms of decrease in spleen size.Cycloguanil pamoate may be of value both for prophylaxis and treatment in areas where tropical splenomegaly syndrome is endemic.
摘要
对19名患有热带脾肿大综合征且肝活检显示窦性淋巴细胞增多的赞比亚患者进行了研究。巨球蛋白血症与热带脾肿大综合征之间的关联再次得到证实。16名患者接受了抗疟药治疗——12名仅接受环氯胍扑酸盐治疗，3名接受环氯胍和氯胍治疗，1名仅接受氯胍治疗。观察了12名患者足够长的时间以评估药物疗效，其中11名患者脾脏大小减小，反应良好。在热带脾肿大综合征流行地区，环氯胍扑酸盐可能对预防和治疗均有价值。
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本文引用的文献
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