热带脾肿大综合征中停用氯胍治疗后的复发情况。
Relapses after withdrawal of proguanil treatment in tropical splenomegaly syndrome.
作者信息
David-West A S
出版信息
Br Med J. 1974 Aug 24;3(5929):499-501. doi: 10.1136/bmj.3.5929.499.
Abstract
After the remission of symptoms and reduction in spleen size while on proguanil therapy four patients with the tropical splenomegaly syndrome defaulted from treatment. The withdrawal of proguanil caused a recrudescence of original symptoms, splenomegaly, and a return of the initially raised serum IgM. Complete return to normal values was again effected with proguanil therapy.The role of the spleen in the tropical splenomegaly syndrome in the production of the raised serum IgM is discussed. These patients should be educated as to the nature of their disease and the importance of continued medical treatment.
摘要
在接受氯胍治疗期间症状缓解且脾脏大小缩小时，4例热带脾肿大综合征患者停止了治疗。停用氯胍导致原有症状复发、脾肿大以及最初升高的血清IgM再次出现。再次使用氯胍治疗后各项指标又完全恢复到正常水平。文中讨论了脾脏在热带脾肿大综合征中产生血清IgM升高方面所起的作用。应该让这些患者了解其疾病的性质以及持续接受治疗的重要性。
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