Stuiver P C, Ziegler J L, Wood J B, Morrow R H, Hutt M S
Br Med J. 1971 Feb 20;1(5746):426-9. doi: 10.1136/bmj.1.5746.426.
A controlled, randomized, double-blind trial of malaria prophylaxis in tropical splenomegaly syndrome showed a significant reduction in spleen size and an improvement of anaemia and symptoms in patients treated with antimalarials compared with control subjects receiving placebo. This study confirms the observations from West Africa and provides further indirect evidence for a malarial aetiology of tropical splenomegaly syndrome.
一项针对热带脾肿大综合征疟疾预防的对照、随机、双盲试验表明，与接受安慰剂的对照组相比，接受抗疟药治疗的患者脾脏大小显著减小，贫血及症状有所改善。该研究证实了西非的观察结果，并为热带脾肿大综合征的疟疾病因提供了进一步的间接证据。
