Wilson J E, Frenkel E P, Pierce A K, Johnson R L, Winga E R, Curry G C, Mierzwiak D S
J Clin Invest. 1971 Mar;50(3):474-80. doi: 10.1172/JCI106515.
This study correlated levels of activated fibrinolysis with the presence, extent, and rate of resolution of angiographically documented pulmonary emboli. Pulmonary emboli demonstrable by angiography were associated with detectable fibrin split products in the serum of 24 of 25 patients. In the absence of increased fibrin split products, pulmonary emboli large enough to be demonstrated by angiography were found in only 2 of 25 positive pulmonary angiograms. Spontaneous resolution of pulmonary emboli could not be correlated with the the concentration or persistence of fibrin split products but did correlate well with the presence of a reversible precipitating cause. Thrombophlebitis in the absence of clinical evidence of pulmonary embolism was not associated with increased concentrations of fibrin split products in eight of nine patients. The one patient with increased fibrin split product concentration had evidence on lung scan of silent pulmonary embolism.
本研究将活化纤维蛋白溶解水平与血管造影记录的肺栓塞的存在、范围及溶解速率相关联。血管造影可显示的肺栓塞与25例患者中24例血清中可检测到的纤维蛋白裂解产物相关。在没有纤维蛋白裂解产物增加的情况下，在25例阳性肺血管造影中，仅有2例发现了大到足以通过血管造影显示的肺栓塞。肺栓塞的自发溶解与纤维蛋白裂解产物的浓度或持续时间无关，但与可逆性促发因素的存在密切相关。在9例患者中，8例无肺栓塞临床证据的血栓性静脉炎与纤维蛋白裂解产物浓度增加无关。纤维蛋白裂解产物浓度增加的1例患者肺部扫描有隐匿性肺栓塞证据。
