Hunter R, Thomson T, Reynolds C M, Pitcher P M
J Neurol Neurosurg Psychiatry. 1974 Mar;37(3):249-51. doi: 10.1136/jnnp.37.3.249.
Paired cerebrospinal fluid (CSF) and serum samples collected from 81 of 241 patients admitted to a district psychiatric hospital during a six month period were assayed for fibrin/fibrinogen degradation products (FDP) using a haemagglutination inhibition technique. FDP were found in all serum samples. Fifteen patients (18·5%) had FDP in the CSF (range 0·7-3·75 μg/ml.) and of these 13 (87%) had associated CSF protein abnormalities and 9 (60%) were hypertensive. Mean serum FDP values were the same (4·4 μg/ml.) in patients with and without FDP in the CSF. Three patients had raised serum FDP concentrations but no FDP in the CSF. The evidence suggests that the presence of FDP in CSF indicates recent central nervous system damage. In this series the most common cause was vascular disease.
采用血凝抑制技术，对一家地区精神病院在六个月期间收治的241例患者中的81例患者采集的配对脑脊液（CSF）和血清样本进行纤维蛋白/纤维蛋白原降解产物（FDP）检测。所有血清样本中均发现有FDP。15例患者（18.5%）的脑脊液中有FDP（范围为0.7 - 3.75μg/ml），其中13例（87%）伴有脑脊液蛋白异常，9例（60%）患有高血压。脑脊液中有FDP和没有FDP的患者的平均血清FDP值相同（4.4μg/ml）。3例患者血清FDP浓度升高，但脑脊液中没有FDP。证据表明，脑脊液中存在FDP表明近期中枢神经系统受到损害。在本系列中，最常见的原因是血管疾病。
