Ulven A J, Romslo I, Varhaug J E, Svanes K
Eur Surg Res. 1979;11(3):154-60. doi: 10.1159/000128062.
Gastric ulcers were produced in rats by local application of acetic acid to the serosal surface of the stomach. In half of the animals the greater omentum was excised just before the application of acid. Gastric mucosal blood flow was estimated by means of the (14C)-aniline clearance technique. Gastric acid secretion was determined under basal conditions and under pentagastrin stimulation. Removal of the greater omentum resulted in accelerated healing of the gastric ulcers. Maximal acid output and mucosal blood flow were found to be decreased in omentectomized animals 24 h after ulcer induction. 3 weeks later the secretion and blood flow in omentectomized animals did not differ significantly from the values of the control animals. The accelerated ulcer healing in omentectomized animals is assumed to be due to decreased acid secretion resulting from decreased mucosal blood flow following partial devascularization of the stomach.
通过将乙酸局部应用于大鼠胃浆膜表面来制造胃溃疡。在一半的动物中，就在施加酸之前切除大网膜。通过（14C）-苯胺清除技术估计胃黏膜血流量。在基础条件下和五肽胃泌素刺激下测定胃酸分泌。切除大网膜导致胃溃疡愈合加速。发现在诱导溃疡后24小时，去大网膜动物的最大酸分泌量和黏膜血流量降低。3周后，去大网膜动物的分泌和血流量与对照动物的值没有显著差异。去大网膜动物溃疡愈合加速被认为是由于胃部分血管化后黏膜血流量减少导致酸分泌减少所致。
