Fisher M W, Hillegas A B, Nazeeri P L
Appl Microbiol. 1971 Jul;22(1):13-6. doi: 10.1128/am.22.1.13-16.1971.
Tests were performed on 64 strains of Pseudomonas pseudomallei to compare rifampin, various tetracyclines, and other antibiotics for inhibitory activity in vitro. Rifampin minimum inhibitory concentration (MIC) values generally fell between 25 to 50 mug/ml. For deoxycycline, methacycline, tetracycline, and minocycline, MIC means ranged from 1.3 to 2.7 mug/ml. Delayed treatment tests in subacute mouse infections revealed a better rifampin activity than was expected from its weak activity in vitro, whereas of the others, minocycline appeared superior. None of these five antibiotics demonstrated fully curative effectiveness in terms of mouse survival or eradication of residual infection in organs.
对64株类鼻疽假单胞菌进行了测试，以比较利福平、各种四环素及其他抗生素的体外抑制活性。利福平的最低抑菌浓度（MIC）值一般在25至50微克/毫升之间。脱氧土霉素、甲烯土霉素、四环素和米诺环素的MIC均值在1.3至2.7微克/毫升之间。亚急性小鼠感染的延迟治疗试验显示，利福平的活性比其体外微弱活性所预期的要好，而在其他药物中，米诺环素似乎更具优势。就小鼠存活或器官中残余感染的根除而言，这五种抗生素均未显示出完全治愈的效果。
