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印度南部一个孤立部落群体的遗传负荷。

Genetic load in an isolated tribal population of South India.

作者信息

Ghosh A K, Majumder P P

出版信息

Hum Genet. 1979 Oct 1;51(2):203-8. doi: 10.1007/BF00287176.

DOI:10.1007/BF00287176
PMID:511147
Abstract

The Kota of Nilgiri Hills, Tamilnadu, are an isolated tribal population and occupy the lowest stratum in the local social hierarchy. They have developed an economic symbiotic relationship with other tribes of the Nilgiri Hills (e.g., Toda, Kurumba, Badaga), but have almost no social relationship with other communities, such as the Hindu and Muslim, communities, etc. The total population of the Kota is about 1200. Consanguineous marriages are highly favoured in this group. This paper presents data on prenatal, infant and adolescent mortality in relation to the degree of inbreeding. No perceptible difference has been found in mortality figures between consanguineous and non-consanguineous marriages. This may be due to the long history of inbreeding among the Kota. No case of visible congenital malformation has been noticed. The estimates of genetic load as revealed by inbreeding data indicate that genetic load in the Kota is low (perhaps about 1 lethal equivalent per gamete); it is also low in comparison with that in other Indian populations.

摘要

泰米尔纳德邦尼尔吉里丘陵地区的科塔人是一个与世隔绝的部落群体,处于当地社会等级制度的最底层。他们与尼尔吉里丘陵的其他部落(如托达人、库伦巴人、巴达加人)建立了经济共生关系,但与印度教和穆斯林等其他社群几乎没有社会联系。科塔人的总人口约为1200人。这个群体非常青睐近亲婚姻。本文呈现了与近亲繁殖程度相关的产前、婴儿及青少年死亡率数据。在近亲婚姻和非近亲婚姻的死亡率数据上未发现明显差异。这可能是由于科塔人长期近亲繁殖的历史。未发现明显的先天性畸形病例。近亲繁殖数据揭示的遗传负荷估计表明,科塔人的遗传负荷较低(可能每个配子约有1个致死当量);与其他印度人群体相比也较低。

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本文引用的文献

1
AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES.根据近亲婚姻数据对人类突变损伤的估计
Proc Natl Acad Sci U S A. 1956 Nov;42(11):855-63. doi: 10.1073/pnas.42.11.855.
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1. The concept of genetic load: a critique.1. 遗传负荷的概念:一种批判。
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3
Selection intensity in the Kota of Nilgiri Hills, Madras.马德拉斯尼尔吉里山科塔人的选择强度。
Soc Biol. 1970 Sep;17(3):224-5. doi: 10.1080/19485565.1970.9987873.
4
ABO blood groups and PTC taste sensitivity among the Kota of Nilgiri Hills.尼尔吉里山科塔人的ABO血型与苯硫脲味觉敏感性
Hum Hered. 1973;23(1):78-82. doi: 10.1159/000152557.
5
Inbreeding load in the newborn of Hyderabad.海得拉巴新生儿的近亲繁殖负荷
Acta Genet Med Gemellol (Roma). 1972 Oct;21(4):327-31. doi: 10.1017/s0001566000010679.
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Inbreeding in the Kota of Nilgiri Hills, Madras.马德拉斯尼尔吉里山科塔人的近亲繁殖现象
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The Kota of the Nilgiri Hills: a demographic study.尼尔吉里丘陵的科塔人:一项人口统计学研究。
J Biosoc Sci. 1976 Jan;8(1):17-26. doi: 10.1017/s0021932000010415.
8
Inbreeding effects on human reproduction in Tamil Nadu of South India.近亲繁殖对印度南部泰米尔纳德邦人类生殖的影响。
Ann Hum Genet. 1977 Jul;41(1):87-98. doi: 10.1111/j.1469-1809.1977.tb01964.x.
9
A population genetic study of the Kota in the Nilgiri Hills, South India.印度南部尼尔吉里丘陵地区科塔人的群体遗传学研究。
Hum Hered. 1977;27(4):225-41. doi: 10.1159/000152873.
10
On consanguineous marriages and the genetic load.关于近亲婚姻与遗传负荷
Hum Genet. 1977 Apr 7;36(1):47-54. doi: 10.1007/BF00390435.