Sorri M, Jokinen K, Peltomäki E
Infection. 1979;7 Suppl 5:S475-7. doi: 10.1007/BF01659776.
The penetration of ampicillin into sinus mucosa and secretion after oral bacampicillin was studied in 30 patients subjected to radical maxillary sinus surgery. Bacampicillin in a dose of 1200 mg was administered orally before the operation and the concentrations in serum, sinus mucosa and secretion were assayed. The mean serum concentration (+/- SEM) reached its maximum of 13.4 +/- 1.2 micrograms/ml in about one hour. The mean concentrations in the secretion and mucosa after two to five hours were 1.6 +/- 0.5 micrograms/ml and 1.6 +/- 0.4 micrograms/ml respectively. The clinical course of the patients was mostly uneventful. Adverse effects probably caused by the drug were found in two cases.
对30例行上颌窦根治术的患者研究了口服巴氨西林后氨苄西林在上颌窦黏膜中的渗透及分泌情况。术前口服1200mg巴氨西林，然后测定血清、上颌窦黏膜及分泌物中的浓度。血清平均浓度（±标准误）在约1小时时达到最高值13.4±1.2μg/ml。2至5小时后分泌物及黏膜中的平均浓度分别为1.6±0.5μg/ml和1.6±0.4μg/ml。患者的临床过程大多平稳。有2例发现了可能由该药物引起的不良反应。
