Kallings L O, Eriksson G, Hoffner S, Linse U B
Infection. 1979;7 Suppl 5:S478-82. doi: 10.1007/BF01659777.
The study comprised 24 male and 24 female patients treated either for uncomplicated gonorrhoea or as a prophylaxis. A single dose of 800 mg of bacampicillin + 1.0 g probenecid was administered orally to each patient. The concentrations of ampicillin in urethra and cervix were assayed by means of alginate swabs that were used as diffusion centres on agar diffusion plates. The inhibition zones were compared with a standard series of swabs containing known amounts of ampicillin. The amounts of secretions absorbed into the swabs were determined by weighing each swab before and after taking the specimen. The median ampicillin concentration in the male urethra one hour after the single dose of bacampicillin plus probenecid was 2.0 micrograms/ml of urethral secretion and increased to 3.2 micrograms/ml two hours after administration of the antibiotic. In the female urethra, the median concentrations of ampicillin were 1.5 micrograms/ml and 2.3 micrograms/ml of urethral secretion one and two hours, respectively, after the same dosage as above. The corresponding ampicillin concentrations in the cervical secretion were 1.6 micrograms/ml and 2.9 micrograms/ml, respectively.
该研究包括24名男性患者和24名女性患者，他们均接受了单纯性淋病治疗或预防治疗。给每位患者口服单剂量800毫克巴卡西林加1.0克丙磺舒。通过藻酸盐拭子测定尿道和宫颈中的氨苄西林浓度，这些拭子用作琼脂扩散板上的扩散中心。将抑菌圈与一系列含有已知量氨苄西林的标准拭子进行比较。通过在采集标本前后称量每个拭子来确定吸收到拭子中的分泌物量。在单剂量巴卡西林加丙磺舒给药后1小时，男性尿道中氨苄西林的中位浓度为每毫升尿道分泌物2.0微克，在使用抗生素2小时后升至3.2微克/毫升。在女性尿道中，在上述相同剂量给药后1小时和2小时，氨苄西林的中位浓度分别为每毫升尿道分泌物1.5微克和2.3微克。宫颈分泌物中相应的氨苄西林浓度分别为1.6微克/毫升和2.9微克/毫升。
