Wallin J, Bengtsson S, Eriksson G, Kallings L O, Sandström E, Wallmark G
Infection. 1979;7 Suppl 5:S487-8. doi: 10.1007/BF01659779.
In a systematic study of dose-response relationship 883 patients with uncomplicated gonorrhoea were given single oral doses of 400, 800 or 1600 mg bacampicillin, with 1 g probenecid. A single dose of bacampicillin 800 mg plus probenecid was the minimum effective dose in patients with fully ampicillin-sensitive strains. In patients with gonococci showing reduced sensitivity to ampicillin, 1600 mg bacampicillin was required to reach a cure rate above 95%. Bacampicillin was well tolerated in all treatment groups. Side-effects were reported in 4.6% of the courses of treatment. The most frequent adverse reaction was loose stools (1.9%), which was noted more often after the 1600 mg dose but was considered to be of no or very little clinical importance.
在一项关于剂量反应关系的系统性研究中，883例无并发症淋病患者单次口服400、800或1600毫克巴氨西林，并加服1克丙磺舒。对于对氨苄西林完全敏感菌株的患者，800毫克巴氨西林加丙磺舒的单次剂量是最小有效剂量。对于对氨苄西林敏感性降低的淋球菌患者，需要1600毫克巴氨西林才能使治愈率高于95%。所有治疗组中巴氨西林的耐受性良好。4.6%的疗程报告有副作用。最常见的不良反应是腹泻（1.9%），在1600毫克剂量后更常出现，但被认为无临床意义或临床意义很小。
