• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis and antiinflammatory activity of some 3-carboxamides of 2-alkyl-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide.

作者信息

Lombardino J G, Wiseman E H, McLamore W M

出版信息

J Med Chem. 1971 Dec;14(12):1171-5. doi: 10.1021/jm00294a008.

DOI:10.1021/jm00294a008
PMID:5116229
Abstract
摘要

相似文献

1
Synthesis and antiinflammatory activity of some 3-carboxamides of 2-alkyl-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide.
J Med Chem. 1971 Dec;14(12):1171-5. doi: 10.1021/jm00294a008.
2
Potent anti-inflammatory N-heterocyclic 3-carboxamides of 4-hydroxy-2-methyl-2H-1,2-benzothiazine 1,1-dioxide.
J Med Chem. 1973 May;16(5):493-6. doi: 10.1021/jm00263a017.
3
Sudoxicam and related N-heterocyclic carboxamides of 4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide. Potent nonsteroidal antiinflammatory agents.舒多昔康及相关的4-羟基-2H-1,2-苯并噻嗪1,1-二氧化物的N-杂环羧酰胺。强效非甾体抗炎药。
J Med Chem. 1972 Aug;15(8):848-9. doi: 10.1021/jm00278a016.
4
Antiinflammatory 3,4-dihydro-2-alkyl-3-oxo-2H-1,2-benzothiazine-4-carboxamide 1,1-dioxides.
J Med Chem. 1971 Oct;14(10):973-7. doi: 10.1021/jm00292a022.
5
1,2-benzothiazines. 6. 3-Carbamoyl-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxides as antiinflammatory agents.
J Med Chem. 1973 Jan;16(1):44-8. doi: 10.1021/jm00259a013.
6
4-(3-(Dimethylamino)propyl)-3,4-dihydro-2-(1-hydroxyethyl)-3-phenyl-2H-1,4-benzothiazine and related compounds. A new class of antiinflammatory agents.
J Med Chem. 1973 Jul;16(7):776-9. doi: 10.1021/jm00265a007.
7
Isoxicam and related 4-hydroxy-N-isoxazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides. Potent nonsteroidal antiinflammatory agents.
J Med Chem. 1982 Jan;25(1):12-8. doi: 10.1021/jm00343a003.
8
[Synthesis and antiinflammatory activity of various 1,4-benzothiazine derivatives].
Farmaco Sci. 1985 May;40(5):369-76.
9
[Synthesis and pharmacologic activity of the carboxamides of pyrazolo-1,2-benzothiazine and isoxazolo-1,2-benzothiazine (I)].吡唑并[1,2 - b]苯并噻嗪和异恶唑并[1,2 - b]苯并噻嗪羧酰胺的合成及药理活性（I）
Farmaco Sci. 1983 Jan;38(1):35-44.
10
Anti-inflammatory and pharmacokinetic properties of sudoxicam N-(2-thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Biochem Pharmacol. 1972 Sep 1;21(17):2323-34. doi: 10.1016/0006-2952(72)90383-8.

引用本文的文献

1
A comprehensive DFT study on piroxicam transition metal complexes (Mn, Fe, Co, Ni, and Zn): implications for computational drug design.吡罗昔康过渡金属配合物（锰、铁、钴、镍和锌）的全面密度泛函理论研究：对计算药物设计的启示
J Mol Model. 2025 Aug 26;31(9):257. doi: 10.1007/s00894-025-06483-9.
2
Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides.多功能吡唑并[1,2 - b]苯并噻嗪乙酰胺的合成、表征、抗菌、细胞毒性及碳酸酐酶抑制活性
Beilstein J Org Chem. 2025 Feb 12;21:348-357. doi: 10.3762/bjoc.21.25. eCollection 2025.
3
2,1-Benzothiazine - (quinolin/thiophen)yl hydrazone frameworks as new monoamine oxidase inhibitory agents; synthesis, and investigation.
2,1-苯并噻嗪-（喹啉/噻吩）基腙骨架作为新型单胺氧化酶抑制剂：合成与研究
RSC Adv. 2023 Jan 9;13(3):1701-1710. doi: 10.1039/d2ra07045f. eCollection 2023 Jan 6.
4
Design, Synthesis and Pharmacological Evaluation of 2-(3-BenzoyI-4-Hydroxy-1,1-Dioxido-2H-Benzo[e][1,2]thiazin-2-yI)-N-(2-Bromophenyl) Acetamide as Antidiabetic Agent.设计、合成及 2-(3-苯甲酰基-4-羟基-1,1-二氧代-2H-苯并[e][1,2]噻嗪-2-基)-N-(2-溴苯基)乙酰胺的药理学评价作为抗糖尿病药物。
Drug Des Devel Ther. 2022 Nov 22;16:4043-4060. doi: 10.2147/DDDT.S379205. eCollection 2022.
5
Identification of Cyclic Sulfonamides with an Arylacetamide Group as α-Glucosidase and α-Amylase Inhibitors: Biological Evaluation and Molecular Modeling.具有芳基乙酰胺基团的环状磺胺类化合物作为α-葡萄糖苷酶和α-淀粉酶抑制剂的鉴定：生物学评价和分子模拟
Pharmaceuticals (Basel). 2022 Jan 17;15(1):106. doi: 10.3390/ph15010106.
6
Synthesis and α-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2-benzo[][1,2]thiazin-2-yl]--arylacetamides: An In Silico and Biochemical Approach.2-[3-(苯甲酰基/4-溴苯甲酰基)-4-羟基-1,1-二氧代-2-苯并[][1,2]噻嗪-2-基]--芳基乙酰胺的合成及α-葡萄糖苷酶抑制活性：一种计算机模拟和生化方法。
Molecules. 2021 May 20;26(10):3043. doi: 10.3390/molecules26103043.
7
A Direct and an Efficient Regioselective Synthesis of 1,2-Benzothiazine 1,1-dioxides, β-Carbolinones, Indolo[2,3-]pyran-1-ones, Indolo[3,2-]pyran-1-ones, Thieno[2,3-]pyran-7-ones and Pyrano[3',4':4,5]imidazo[1,2-]pyridin-1-ones via Tandem Stille/Heterocyclization Reaction.通过串联 Stille/杂环化反应，直接、高效地合成 1,2-苯并噻嗪 1,1-二氧化物、β-咔啉酮、吲哚[2,3-b]吡喃-1-酮、吲哚[3,2-b]吡喃-1-酮、噻吩并[2,3-b]吡喃-7-酮和吡喃并[3',4':4,5]咪唑并[1,2-a]吡啶-1-酮。
Molecules. 2020 Nov 4;25(21):5137. doi: 10.3390/molecules25215137.
8
Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond.昔布类，非甾体类抗炎药及其以外的药物。
IUBMB Life. 2014 Dec;66(12):803-11. doi: 10.1002/iub.1334. Epub 2014 Dec 23.
9
2-[(E)-1,1-Dioxo-2-(2,4,5-tri-fluoro-benz-yl)-3,4-di-hydro-2H-1,2-benzo-thia-zin-4-yl-idene]acetic acid.2-[(E)-1,1-二氧代-2-(2,4,5-三氟苄基)-3,4-二氢-2H-1,2-苯并噻嗪-4-亚基]乙酸
Acta Crystallogr Sect E Struct Rep Online. 2014 Jun 14;70(Pt 7):o775. doi: 10.1107/S1600536814013245. eCollection 2014 Jul 1.
10
2-[(Z)-1,1-Dioxo-2-(2,4,5-tri-fluoro-benz-yl)-3,4-di-hydro-2H-1,2-benzo-thia-zin-4-yl-idene]acetic acid.2-[(Z)-1,1-二氧代-2-(2,4,5-三氟苄基)-3,4-二氢-2H-1,2-苯并噻嗪-4-亚基]乙酸
Acta Crystallogr Sect E Struct Rep Online. 2014 May 3;70(Pt 6):o627. doi: 10.1107/S1600536814008903. eCollection 2014 Jun 1.