Jaeger J J, Sylvester J T, Cymerman A, Berberich J J, Denniston J C, Maher J T
J Appl Physiol Respir Environ Exerc Physiol. 1979 Oct;47(4):670-6. doi: 10.1152/jappl.1979.47.4.670.
To determine if subclinical pulmonary edema occurs commonly at high altitude, 25 soldiers participated in two consecutive 72-h field exercises, the first at low altitude (200-875 m) and the second at high altitude (3,000-4,300 m). Various aspects of ventilatory function and pulmonary mechanics were measured at 0, 36, and 72 h of each exercise. Based on physical examination and chest radiographs there was no evidence of pulmonary edema at high altitude. There was, however, an immediate and sustained decrease in vital capacity and transthoracic electrical impedance as well as a clockwise rotation of the transpulmonary pressure-volume curve. In contrast, closing capacity and residual volume did not change immediately upon arrival at high altitude but did increase later during the exposure. These observations are consistent with an abrupt increase in thoracic intravascular fluid volume upon arrival at high altitude followed by a more gradual increase in extravascular fluid volume in the peribronchial spaces of dependent lung regions.
为了确定亚临床肺水肿在高海拔地区是否普遍发生，25名士兵参加了连续两次为期72小时的野外演习，第一次在低海拔地区（200 - 875米），第二次在高海拔地区（3000 - 4300米）。在每次演习的0、36和72小时测量通气功能和肺力学的各个方面。根据体格检查和胸部X光片，高海拔地区没有肺水肿的迹象。然而，肺活量和经胸电阻抗立即且持续下降，以及跨肺压力 - 容积曲线顺时针旋转。相比之下，闭合气量和残气量在到达高海拔地区时没有立即变化，但在暴露后期确实增加了。这些观察结果与到达高海拔地区时胸内血管内液量突然增加，随后在下垂肺区域的支气管周围间隙中血管外液量逐渐增加一致。
