Cerretelli P, Pendergast D, Paganelli W C, Rennie D W
J Appl Physiol Respir Environ Exerc Physiol. 1979 Oct;47(4):761-9. doi: 10.1152/jappl.1979.47.4.761.
The relationship between half time of the O2 uptake on-response (t1/2 VO2on, seconds) and early blood lactate accumulation (delta Lab, mmol.1(-1) at the onset of submaximal arm and/or leg exercise was the object of a cross-sectional study of sedentary subjects (S,n = 3), and kayakers (K, n = 8), and of a longitudinal study on 11 untrained subjects of specific arm vs. leg training. In supine arm cranking (W = 125 watts) S had an average t1/2 VO2on of 82 s and a delta Aab of 9.2 mmol.1(-1) compared to 47 +/- 7 s and 4 +/- 1.4 mmol.1(-1), respectively, for K. In longitudinal trainees shorter t1/2 VO2on was accompanied by lower Lab for the trained limbs. Specific limb conditioning in swimmers and runners resulted in shorter t1/2 VO2on. A linear relationship was observed between delta Lab and t1/2 VO2on having an intercept on the time axis at congruent to 20 s and a slope proportional to muscle mass. Trained muscles were grouped closest to the intercept indicating local acceleration of the rate of O2 transfer approaching the t1/2 VO2on for isolated perfused muscle at the onset of work. Since t1/2 VO2on, we conclude that factors distal to the capillary are specifically involved in the local training response.
氧摄取开启反应的半衰期（t1/2 VO2on，单位：秒）与次最大强度手臂和/或腿部运动开始时早期血乳酸积累（δLab，单位：mmol·L⁻¹）之间的关系，是针对久坐不动的受试者（S组，n = 3）、皮划艇运动员（K组，n = 8）进行的一项横断面研究，以及针对11名未经训练的受试者进行的特定手臂与腿部训练的纵向研究的对象。在仰卧位手臂曲柄运动（功率W = 125瓦）中，S组的平均t1/2 VO2on为82秒，δLab为9.2 mmol·L⁻¹，相比之下，K组分别为47±7秒和4±1.4 mmol·L⁻¹。在纵向训练的受试者中，训练肢体的t1/2 VO2on较短伴随着较低的Lab。游泳运动员和跑步运动员的特定肢体训练导致t1/2 VO2on缩短。观察到δLab与t1/2 VO2on之间存在线性关系，在时间轴上的截距约为20秒，斜率与肌肉质量成正比。训练过的肌肉最接近截距，表明在工作开始时，孤立灌注肌肉的氧转运速率接近t1/2 VO2on时局部加速。由于t1/2 VO2on，我们得出结论，毛细血管远端的因素特别参与了局部训练反应。
