Barber D L, Finco D R
J Am Vet Med Assoc. 1979 Dec 1;175(11):1183-90.
Unilateral bacterial pyelonephritis was induced in nine dogs. The upper urinary tracts of these and six control dogs were evaluated by excretory urography prior to and 9 to 10 days following experimental manipulations. Two of the dogs with unilateral pyelonephritis and one control dog were evaluated at intervals throughout a 58-day period. At necropsy, all nine inoculated kidneys were infected, one experimental dog had bilateral pyelonephritis, and one control dog had unilateral pyelonephritis. Most of the infected kidneys had abnormal radiographic changes 9 to 10 days after induction of infection. There was no statistically significant radiographic change in size of infected kidneys at 9 to 10 days. Seven of the 11 infected kidneys and 7 of the 9 inoculated kidneys had renal pelvic and ureteral dilatation. Of the nine dogs with unilateral pyelonephritis, six had decreased opacity of contrast medium in the collecting system and of the vascular nephrogram on the infected side. The size of infected kidneys decreased progressively during the 58-day period. In one of the two dogs evaluated throughout the period, the collecting system of the infected kidney remained dilated; in the other, it returned toward normal size.
在9只犬中诱发单侧细菌性肾盂肾炎。在实验操作前以及操作后9至10天,通过排泄性尿路造影对这些犬以及6只对照犬的上尿路进行评估。在58天的时间段内,对2只患有单侧肾盂肾炎的犬和1只对照犬进行了定期评估。尸检时,所有9只接种的肾脏均被感染,1只实验犬患有双侧肾盂肾炎,1只对照犬患有单侧肾盂肾炎。大多数受感染的肾脏在感染诱发后9至10天出现异常的影像学改变。在9至10天时,受感染肾脏的大小在影像学上没有统计学显著变化。11只受感染的肾脏中有7只,9只接种的肾脏中有7只出现肾盂和输尿管扩张。在9只患有单侧肾盂肾炎的犬中,6只在感染侧的集合系统和血管肾图中造影剂的密度降低。在58天的时间段内,受感染肾脏的大小逐渐减小。在整个时间段内接受评估的2只犬中,有1只受感染肾脏的集合系统仍处于扩张状态;另一只则恢复到正常大小。