体内大鼠脑内D-β-羟基（¹⁴C）丁酸和（3-¹⁴C）乙酰乙酸的标记掺入氨基酸的情况。
Incorporation of label from D- -hydroxy( 14 C)butyrate and (3- 14 C)acetoacetate into amino acids in rat brain in vivo.
作者信息
Cremer J E
出版信息
Biochem J. 1971 Apr;122(2):135-8. doi: 10.1042/bj1220135.
Abstract
The metabolism of ketone bodies by rat brain was studied in vivo. Rats starved for 48h were given either d-beta-hydroxy[3-(14)C]butyrate or [3-(14)C]acetoacetate by intravenous injection and killed after 3 or 10min. Total radioactivity in the acid-soluble material of the brain and the specific radioactivities of the brain amino acids glutamate, glutamine, aspartate and gamma-aminobutyrate were determined. A group of fed animals were also given d-beta-hydroxy[3-(14)C]butyrate. In the brains of all animals (14)C was present in the acid-soluble material and the specific radioactivity of glutamate was greater than that of glutamine.
摘要
在体内研究了大鼠脑对酮体的代谢。将饥饿48小时的大鼠通过静脉注射给予d-β-羟基[3-(14)C]丁酸酯或[3-(14)C]乙酰乙酸酯，并在3或10分钟后处死。测定了脑酸溶性物质中的总放射性以及脑氨基酸谷氨酸、谷氨酰胺、天冬氨酸和γ-氨基丁酸的比放射性。还对一组喂食的动物给予d-β-羟基[3-(14)C]丁酸酯。在所有动物的脑中，酸溶性物质中存在(14)C，且谷氨酸的比放射性大于谷氨酰胺的比放射性。
相似文献
1
Incorporation of label from D- -hydroxy( 14 C)butyrate and (3- 14 C)acetoacetate into amino acids in rat brain in vivo.体内大鼠脑内D-β-羟基（¹⁴C）丁酸和（3-¹⁴C）乙酰乙酸的标记掺入氨基酸的情况。
Biochem J. 1971 Apr;122(2):135-8. doi: 10.1042/bj1220135.
2
ENTRY OF GLUCOSE CARBON INTO AMINO ACIDS OF RAT BRAIN AND LIVER IN VIVO AFTER INJECTION OF UNIFORMLY 14-C-LABELLED GLUCOSE.注射均匀标记的¹⁴C葡萄糖后，大鼠脑和肝脏中葡萄糖碳在体内进入氨基酸的情况。
Biochem J. 1965 Feb;94(2):345-52. doi: 10.1042/bj0940345.
3
The fuel of respiration of rat kidney cortex.大鼠肾皮质呼吸的燃料。
Biochem J. 1969 Apr;112(2):149-66. doi: 10.1042/bj1120149.
4
Turnover rates of ketone bodies in normal, starved and alloxan-diabetic rats.正常、饥饿和四氧嘧啶糖尿病大鼠体内酮体的周转率
Biochem J. 1968 Dec;110(4):655-61. doi: 10.1042/bj1100655.
5
Acetoacetate metabolism in infant and adult rat brain in vitro.幼年和成年大鼠脑内乙酰乙酸代谢的体外研究
Biochem J. 1970 Feb;116(4):641-55. doi: 10.1042/bj1160641.
6
Ketone-body utilization by adult and suckling rat brain in vivo.成年和哺乳大鼠大脑在体内对酮体的利用
Biochem J. 1971 Mar;122(1):13-8. doi: 10.1042/bj1220013.
7
D-beta-Hydrozybutyrate: a major precursor of amino acids in developing rat brain.
J Neurochem. 1975 Aug;25(2):161-70. doi: 10.1111/j.1471-4159.1975.tb12244.x.
8
Selective inhibition of glucose oxidation by triethyltin in rat brain in vivo.三乙锡对大鼠脑葡萄糖氧化的体内选择性抑制作用。
Biochem J. 1970 Aug;119(1):95-102. doi: 10.1042/bj1190095.
9
Metabolism of glutamate and related amino acids in the 10-day-old mouse brain: experiments with labelled acetate and beta-hydroxybutyrate.
J Neurochem. 1976 Dec;27(6):1449-53. doi: 10.1111/j.1471-4159.1976.tb02628.x.
10
Incorporation of carbon atoms from glucose into free amino acids in brain under normal and altered conditions.
Can J Biochem. 1970 Mar;48(3):228-35. doi: 10.1139/o70-042.
引用本文的文献
1
β-Hydroxybutyrate Boosts Mitochondrial and Neuronal Metabolism but is not Preferred Over Glucose Under Activated Conditions.β-羟基丁酸可促进线粒体和神经元代谢，但在激活条件下并不比葡萄糖更具优势。
Neurochem Res. 2017 Jun;42(6):1710-1723. doi: 10.1007/s11064-017-2228-6. Epub 2017 Mar 18.
2
β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms.大脑中的β-羟基丁酸：一种分子，多种机制。
Neurochem Res. 2017 Jan;42(1):35-49. doi: 10.1007/s11064-016-2099-2. Epub 2016 Nov 8.
3
Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice.乙酰乙酸可加速小鼠肌肉再生并改善肌肉萎缩。
J Biol Chem. 2016 Jan 29;291(5):2181-95. doi: 10.1074/jbc.M115.676510. Epub 2015 Dec 8.
4
Metabolic Alterations in Developing Brain After Injury: Knowns and Unknowns.脑损伤后发育中大脑的代谢改变：已知与未知
Neurochem Res. 2015 Dec;40(12):2527-43. doi: 10.1007/s11064-015-1600-7. Epub 2015 Jul 7.
5
Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis.醋酸盐补充可增加脑磷酸肌酸并降低 AMP 水平，但对线粒体生物发生没有影响。
Neurochem Int. 2013 Feb;62(3):296-305. doi: 10.1016/j.neuint.2013.01.004. Epub 2013 Jan 12.
6
Cortical substrate oxidation during hyperketonemia in the fasted anesthetized rat in vivo.在禁食麻醉大鼠体内高酮血症期间的皮质基底氧化。
J Cereb Blood Flow Metab. 2011 Dec;31(12):2313-23. doi: 10.1038/jcbfm.2011.91. Epub 2011 Jul 6.
7
[2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain.[2,4-¹³C₂]-β-羟基丁酸在人脑中的代谢
J Cereb Blood Flow Metab. 2002 Jul;22(7):890-8. doi: 10.1097/00004647-200207000-00014.
8
Incorporation of label from(1- 14 C)ethanol into the glutamate-glutamine pools of rat brain in vivo.（1-¹⁴C）乙醇中的标记物在大鼠脑内谷氨酸-谷氨酰胺池中的体内掺入情况。
Biochem J. 1972 Feb;126(3):467-9. doi: 10.1042/bj1260467.
9
The interconversion and disposal of ketone bodies in untreated and injured post-absorptive rats.未处理及受伤的空腹大鼠体内酮体的相互转化与代谢
Biochem J. 1973 Nov;136(3):531-43. doi: 10.1042/bj1360531.
10
The estimation of rates of utilization of glucose and ketone bodies in the brain of the suckling rat using compartmental analysis of isotopic data.利用同位素数据的房室分析来估计乳鼠大脑中葡萄糖和酮体的利用率。
Biochem J. 1974 Sep;142(3):527-44. doi: 10.1042/bj1420527.
本文引用的文献
1
Utilization in vivo of glucose and volatile fatty acids by sheep brain for the synthesis of acidic amino acids.绵羊脑内葡萄糖和挥发性脂肪酸用于合成酸性氨基酸的体内利用。
Biochem J. 1966 Dec;101(3):591-7. doi: 10.1042/bj1010591.
2
ENTRY OF GLUCOSE CARBON INTO AMINO ACIDS OF RAT BRAIN AND LIVER IN VIVO AFTER INJECTION OF UNIFORMLY 14-C-LABELLED GLUCOSE.注射均匀标记的¹⁴C葡萄糖后，大鼠脑和肝脏中葡萄糖碳在体内进入氨基酸的情况。
Biochem J. 1965 Feb;94(2):345-52. doi: 10.1042/bj0940345.
3
AMINO ACID METABOLISM IN RAT BRAIN STUDIED WITH 14C-LABELLED GLUCOSE.用¹⁴C标记葡萄糖研究大鼠脑内的氨基酸代谢。
J Neurochem. 1964 Mar;11:165-85. doi: 10.1111/j.1471-4159.1964.tb06127.x.
4
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.血液中D(-)-β-羟基丁酸和乙酰乙酸的酶法测定
Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
5
Brain metabolism during fasting.禁食期间的脑代谢。
J Clin Invest. 1967 Oct;46(10):1589-95. doi: 10.1172/JCI105650.
6
The effect of periodic convulsions induced by 1,1-dimethylhydrazine on the synthesis of rat brain metabolites from [2-14C]glucose.1,1-二甲基肼诱发的周期性惊厥对大鼠脑代谢物从[2-¹⁴C]葡萄糖合成的影响。
J Neurochem. 1966 Jan;13(1):1-11. doi: 10.1111/j.1471-4159.1966.tb10279.x.
7
Precursors in vivo of glutamate, aspartate and their derivatives of rat brain.大鼠脑内谷氨酸、天冬氨酸及其衍生物的体内前体物质。
J Neurochem. 1966 Sep;13(9):835-47. doi: 10.1111/j.1471-4159.1966.tb05879.x.
8
Compartmentation of glutamate metabolism in brain. Evidence for the existence of two different tricarboxylic acid cycles in brain.大脑中谷氨酸代谢的区室化。大脑中存在两种不同三羧酸循环的证据。
Biochem J. 1969 Jun;113(2):281-90. doi: 10.1042/bj1130281.
9
Turnover rates of ketone bodies in normal, starved and alloxan-diabetic rats.正常、饥饿和四氧嘧啶糖尿病大鼠体内酮体的周转率
Biochem J. 1968 Dec;110(4):655-61. doi: 10.1042/bj1100655.
10
Metabolism of [14C]leucine and [14C]acetate in sensorimotor cortex, thalamus, caudate nucleus and cerebellum of the cat.猫的感觉运动皮层、丘脑、尾状核和小脑中[14C]亮氨酸和[14C]乙酸盐的代谢
J Neurochem. 1968 Sep;15(9):965-70. doi: 10.1111/j.1471-4159.1968.tb11639.x.
Zotero 插件