三乙锡对大鼠脑葡萄糖氧化的体内选择性抑制作用。
Selective inhibition of glucose oxidation by triethyltin in rat brain in vivo.
作者信息
Cremer J E
出版信息
Biochem J. 1970 Aug;119(1):95-102. doi: 10.1042/bj1190095.
Abstract
Results are reported of a comparative study in vivo of the metabolism of [2-(14)C]-glucose and [1-(14)C]acetate in brains of rats intoxicated with triethyltin sulphate. The incorporation of (14)C from glucose into glutamate, glutamine, gamma-aminobutyrate and aspartate was greatly decreased. The incorporation of (14)C from acetate into these amino acids was unaffected. The experimental data indicated that the main action of triethyltin was to decrease the rate at which pyruvate formed from glucose is oxidized. Glycolysis was not inhibited. Changes in glucose metabolism in the brain are shown not to be directly due to hypothermia. Some of the advantages of measuring the labelling of intermediates at very short time intervals after the injection of the labelled glucose are demonstrated.
摘要
报告了在硫酸三乙锡中毒的大鼠脑中，对[2-(14)C]-葡萄糖和[1-(14)C]乙酸代谢进行体内比较研究的结果。葡萄糖中的(14)C掺入谷氨酸、谷氨酰胺、γ-氨基丁酸和天冬氨酸的量大大减少。乙酸中的(14)C掺入这些氨基酸不受影响。实验数据表明，三乙锡的主要作用是降低由葡萄糖形成的丙酮酸的氧化速率。糖酵解未受抑制。结果表明，脑中葡萄糖代谢的变化并非直接由体温过低引起。还展示了在注射标记葡萄糖后极短时间间隔内测量中间产物标记的一些优点。
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