4-N-氨酰基福提米星E。
4-N-Aminoacylfortimicins E.
作者信息
Kurath P, Grampovnik D, Tadanier J, Martin J R, Egan R S, Stanaszek R S, Cirovic M, Washburn W H, Hill P, Dunnigan D A, Leonard J E, Johnson P, Goldstein A W
出版信息
J Antibiot (Tokyo). 1979 Sep;32(9):884-90. doi: 10.7164/antibiotics.32.884.
PMID:511780
Abstract
The conversion of fortimicin E, a minor metabolite from the Micromonospora olivoasterospora fermentation which also produces fortimicin A and fortimicin B, to four 4-N-aminoacylfortimicins E was accomplished. The new 4-N-aminoacylfortimicins E showed only weak antimicrobial activity against several Gram-negative and Gram-positive microorganisms.
摘要
将来自橄榄小单孢菌发酵的次要代谢产物弗氏霉素E（该发酵过程还产生弗氏霉素A和弗氏霉素B）转化为四种4-N-氨酰弗氏霉素E的过程得以实现。新型4-N-氨酰弗氏霉素E对几种革兰氏阴性菌和革兰氏阳性菌仅表现出微弱的抗菌活性。
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