Kurath P, Stanaszek R S, Cirovic M
J Antibiot (Tokyo). 1982 Oct;35(10):1338-44. doi: 10.7164/antibiotics.35.1338.
The preparations of 4-N-glycyllysinomicin and several 4-N-aminoacyl derivatives of compounds prepared from lysinomicin are presented. The new substances have lower antimicrobial activities than the original 4-N-unsubstituted lysinomicin derivatives. This result indicates that the structure-activity relationship observed with fortimicin A and fortimicin B does not apply to the lysinomicin derivatives studied.
介绍了4-N-甘氨酰赖氨酸霉素及由赖氨酸霉素制备的几种4-N-氨基酰基衍生物的制备方法。这些新物质的抗菌活性低于原来的4-N-未取代赖氨酸霉素衍生物。该结果表明，在福提霉素A和福提霉素B中观察到的构效关系不适用于所研究的赖氨酸霉素衍生物。
