婴儿期呼吸道合胞病毒疾病的发病机制。
Pathogenesis of respiratory syncytial virus diseases in infancy.
作者信息
Ross C A, Pinkerton I W, Assaad F A
出版信息
Arch Dis Child. 1971 Oct;46(249):702-4. doi: 10.1136/adc.46.249.702.
In a series of 54 children under 1 year old with respiratory syncytial virus infection, the highest proportion of severe illnesses (bronchiolitis and pneumonia), and the highest proportion of `slow' antibody responses, were found in children under 6 months. Severe illness may therefore be related to immunological immaturity and to lack of protection by maternal antibody, rather than to an allergic response as has been suggested. A high male to female ratio (approximately 2: 1) was found both in the present series, and in two larger series of respiratory syncytial virus infection in infants.
在一组54名1岁以下感染呼吸道合胞病毒的儿童中，6个月以下的儿童出现重症（细支气管炎和肺炎）的比例最高，“缓慢”抗体反应的比例也最高。因此，重症可能与免疫不成熟以及缺乏母体抗体的保护有关，而非如有人所提出的与过敏反应有关。在本系列研究以及另外两项关于婴儿呼吸道合胞病毒感染的更大规模研究中，均发现男性与女性的比例较高（约为2:1）。
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