Berry C L
Arch Dis Child. 1971 Oct;46(249):709-11. doi: 10.1136/adc.46.249.709.
In an experimental system using rats, prepubertal treatment with cyclophosphamide was associated with slightly reduced fertility of the adult female. No malformations were noted in the offspring, and there was no change in the size of the rat pups produced. Reduction in litter size was apparent by day 11 of gestation, suggesting that losses before or around implantation were the most likely cause of the reduction in litter size. The relevance of these results to cytotoxic drug therapy in the nephrotic syndrome in childhood is considered.
在一个使用大鼠的实验系统中，青春期前用环磷酰胺治疗与成年雌性大鼠的生育能力略有下降有关。后代未发现畸形，所产幼鼠的大小也没有变化。到妊娠第11天，窝仔数明显减少，这表明植入前或植入前后的损失最有可能是窝仔数减少的原因。文中还考虑了这些结果与儿童肾病综合征细胞毒性药物治疗的相关性。
