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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Biochem J. 1971 Feb;121(3):447-52. doi: 10.1042/bj1210447.

Incubation of rat liver homogenate with [1-(14)C]glyoxylate, ATP and acetate shows a rapid sequential incorporation of radioactivity into malate, oxaloacetate and citrate. 2. In liver from normal rats the rate of the formation of each substance in question is higher than that in liver from thiamin-deficient rats. 3. The net accumulation of malate is greater with liver from thiamin-deficient rats. Its further metabolism is retarded, it is suggested, by inhibitors formed by a condensation of glyoxylate and oxaloacetate.

用[1-(14)C]乙醛酸、ATP和乙酸盐对大鼠肝脏匀浆进行温育，结果显示放射性迅速依次掺入苹果酸、草酰乙酸和柠檬酸中。2. 在正常大鼠的肝脏中，上述每种物质的形成速率均高于硫胺素缺乏大鼠肝脏中的形成速率。3. 硫胺素缺乏大鼠肝脏中苹果酸的净积累量更大。据推测，乙醛酸和草酰乙酸缩合形成的抑制剂阻碍了苹果酸的进一步代谢。

Biochem J. 1971 Feb;121(3):447-52. doi: 10.1042/bj1210447.

Incubation of rat liver homogenate with [1-(14)C]glyoxylate, ATP and acetate shows a rapid sequential incorporation of radioactivity into malate, oxaloacetate and citrate. 2. In liver from normal rats the rate of the formation of each substance in question is higher than that in liver from thiamin-deficient rats. 3. The net accumulation of malate is greater with liver from thiamin-deficient rats. Its further metabolism is retarded, it is suggested, by inhibitors formed by a condensation of glyoxylate and oxaloacetate.

用[1-(14)C]乙醛酸、ATP和乙酸盐对大鼠肝脏匀浆进行温育，结果显示放射性迅速依次掺入苹果酸、草酰乙酸和柠檬酸中。2. 在正常大鼠的肝脏中，上述每种物质的形成速率均高于硫胺素缺乏大鼠肝脏中的形成速率。3. 硫胺素缺乏大鼠肝脏中苹果酸的净积累量更大。据推测，乙醛酸和草酰乙酸缩合形成的抑制剂阻碍了苹果酸的进一步代谢。