Rouger P, Riveau D, Salmon C, Loygue J
J Clin Pathol. 1979 Sep;32(9):907-11. doi: 10.1136/jcp.32.9.907.
The levels of A, H, I, and i plasma antigens and of anti-B, anti-I, and anti-T antibodies were measured in 70 subjects with colonic or gastric carcinoma. These studies showed a significant increase in A plasma activity of the A subjects, and in H plasma activity of the O subjects, while 25% of the tested subjects showed increased I plasma activity. There was no difference in i plasma activity between cancer patients and healthy subjects. These results take into account the marked polymorphism acquired by neoplastic tissue, which is capable also of producing a greater quantity of antigens than that of healthy subjects. Nevertheless this heterogeneity forms a barrier to the clinical measurement of these plasma antigens for screening neoplasms. The significant fall in the amount of anti-T antibodies seemed to be secondary to the absorption of these antibodies on the surface of the tumour cells.
对70例结肠癌或胃癌患者测定了A、H、I和i血浆抗原水平以及抗B、抗I和抗T抗体水平。这些研究表明，A型受试者的A血浆活性显著增加，O型受试者的H血浆活性显著增加，而25%的受试对象显示I血浆活性增加。癌症患者和健康受试者的i血浆活性没有差异。这些结果考虑到了肿瘤组织获得的显著多态性，肿瘤组织也能够产生比健康受试者更多的抗原。然而，这种异质性成为这些血浆抗原用于肿瘤筛查临床检测的障碍。抗T抗体量的显著下降似乎是由于这些抗体在肿瘤细胞表面的吸附所致。
