Lechin F, van der Dijs B
Acta Gastroenterol Latinoam. 1979;9(3):145-52.
Diphenylhydantoin (DPH) induced changes in distal colon motility in the 37 subjects investigated. In subjects with sigmoidal hyperactivity plus rectal hypoactivity, DPH suppressed or reduced sigmoidal phasic activity. In subjects showing no sigmoidal activity predominance, DPH induced increases of sigmoidal and/or rectal motility. Sulpiride (an "atypical" dopaminergic blocking agent) antagonized DPH-induced changes. Our results strongly suggest that DPH-induced distal motility changes are mediated by the dopaminergic and noradrenergic systems.
在研究的37名受试者中，苯妥英（DPH）引起了远端结肠运动的变化。在患有乙状结肠活动亢进加直肠活动减退的受试者中，DPH抑制或降低了乙状结肠的阶段性活动。在没有乙状结肠活动优势的受试者中，DPH引起乙状结肠和/或直肠运动增加。舒必利（一种“非典型”多巴胺能阻滞剂）拮抗DPH诱导的变化。我们的结果强烈表明，DPH诱导的远端运动变化是由多巴胺能和去甲肾上腺素能系统介导的。
