母亲镰状细胞性状对围产期死亡率的影响。
Effect of maternal sickle-cell trait on perinatal mortality.
作者信息
Platt H S
出版信息
Br Med J. 1971 Nov 6;4(5783):334-6. doi: 10.1136/bmj.4.5783.334.
Abstract
Possession of the sickle-cell trait (Hb AS) by the African mother has been shown to be associated with a significant increase in perinatal mortality when there is anoxic stress. This observation should be taken into consideration in the management of labour of both the indigenous and immigrant mothers at risk. The findings do not influence the proposed explanations for the maintenance of high frequencies of the haemoglobin S gene in areas of endemic malaria.
摘要
非洲母亲携带镰状细胞性状（Hb AS）已被证明，在存在缺氧应激时，围产期死亡率会显著增加。在管理有风险的本地和移民产妇分娩时，应考虑到这一观察结果。这些发现并不影响对疟疾流行地区血红蛋白S基因高频率维持现象的现有解释。
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