Dalmaz Y, Peyrin L, Sann L, Dutruge J
J Neural Transm. 1979;46(2):153-74. doi: 10.1007/BF01250336.
Catecholamines (dopamine [DA], norepinephrine [NE], epinephrine [E]), methoxyamines (3-methoxytyramine [MT], normetanephrine [NMN], metanephrine [MN]), DOPA, and acidic metabolites (3,4-dihydroxyphenylacetic acid [DOPAC], vanilmandelic acid [VMA]) were determined in human urines from one day of age to adulthood, in order to investigate sympatho-adrenal development during life. All adrenergic compounds are present in neonate urines on the first day of life, but their postnatal evolution is quite different according to the nature of metabolites. Daily E, MN and VMA amounts remain low until the 10th month of life; daily NE, MT and DOPA levels increase progressively, but, in contrast, NMN amounts are already high in the neonatal period and increase only beyond the fourth year of age. DA is at either age the predominant catecholamine but its elimination is relatively more important in the neonatal period.
为了研究一生中交感 - 肾上腺的发育情况，测定了从1日龄到成年期人类尿液中的儿茶酚胺（多巴胺[DA]、去甲肾上腺素[NE]、肾上腺素[E]）、甲氧基胺（3 - 甲氧基酪胺[MT]、去甲变肾上腺素[NMN]、变肾上腺素[MN]）、多巴以及酸性代谢产物（3,4 - 二羟基苯乙酸[DOPAC]、香草扁桃酸[VMA]）。所有肾上腺素能化合物在出生第一天的新生儿尿液中均有存在，但根据代谢产物的性质，它们出生后的演变情况差异很大。每日E、MN和VMA的量在出生后第10个月之前一直保持在较低水平；每日NE、MT和多巴水平逐渐升高，但相比之下，NMN的量在新生儿期就已经很高，且仅在4岁以后才会增加。DA在任何年龄段都是主要的儿茶酚胺，但其在新生儿期的清除相对更为重要。
