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胆固醇与大鼠肝脏线粒体一起孵育生成石胆酸、鹅去氧胆酸以及α-和β-鼠胆酸。

The formation of lithocholic acid, chenodeoxycholic acid and alpha- and beta-muricholic acids from cholesterol incubated with rat-liver mitochondria.

作者信息

Mitropoulos K A, Myant N B

出版信息

Biochem J. 1967 May;103(2):472-9. doi: 10.1042/bj1030472.

DOI:10.1042/bj1030472
PMID:6047622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1270430/
Abstract
  1. When rat-liver mitochondria were incubated with [4-(14)C]cholesterol in the presence of a soluble supernatant fraction, various steroids more polar than cholesterol were formed. These included 3beta-hydroxycholest-5-en-26-oic acid, 3beta-hydroxychol-5-enoic acid, lithocholic acid, chenodeoxycholic acid and alpha- and beta-muricholic acids. 2. All the radioactive C(24) bile acids recovered were in conjugated form, probably as taurine conjugates. 3. The formation of 3beta-hydroxychol-5-enoic acid from cholesterol shows that liver mitochondria are capable of carrying out the oxidative removal of the isopropyl unit of the side chain before any modification has occurred in the ring system.
摘要
  1. 当大鼠肝脏线粒体与[4-(14)C]胆固醇在可溶性上清液组分存在的情况下一起温育时，形成了各种比胆固醇极性更强的类固醇。这些包括3β-羟基胆甾-5-烯-26-酸、3β-羟基胆-5-烯酸、石胆酸、鹅去氧胆酸以及α-和β-鼠胆酸。2. 回收的所有放射性C(24)胆汁酸均为结合形式，可能是牛磺酸结合物。3. 由胆固醇形成3β-羟基胆-5-烯酸表明，肝脏线粒体能够在环系统发生任何修饰之前，对侧链的异丙基单元进行氧化去除。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/9b55fdfe12ce/biochemj00743-0194-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/7091a9526654/biochemj00743-0191-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/186c818cc798/biochemj00743-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/2c0a99ecfbd1/biochemj00743-0192-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/269f974036cd/biochemj00743-0193-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/0540f5fc65ca/biochemj00743-0193-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/e3d1286b279d/biochemj00743-0194-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/9b55fdfe12ce/biochemj00743-0194-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/7091a9526654/biochemj00743-0191-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/186c818cc798/biochemj00743-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/2c0a99ecfbd1/biochemj00743-0192-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/269f974036cd/biochemj00743-0193-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/0540f5fc65ca/biochemj00743-0193-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/e3d1286b279d/biochemj00743-0194-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4053/1270430/9b55fdfe12ce/biochemj00743-0194-b.jpg

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本文引用的文献

1
The metabolism of cholesterol in the presence of liver mitochondria from normal and thyroxine-treated rats.正常大鼠和经甲状腺素处理的大鼠肝脏线粒体存在时胆固醇的代谢
Biochem J. 1965 Mar;94(3):594-603. doi: 10.1042/bj0940594.
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Bile acids. XVI. Metabolism of cholanic acid-24-C-14 in the rat.胆汁酸。十六。大鼠体内胆烷酸-24-C-14的代谢
J Biol Chem. 1961 Dec;236:3158-62.
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BILE ACIDS. XXI. METABOLISM OF 3-ALPHA,6-BETA-DIHYDROXY-5-BETA-CHOLANOIC ACID-24-C 14-6-ALPHA-H3 IN THE RAT.胆汁酸。二十一。大鼠体内3-α,6-β-二羟基-5-β-胆烷酸-24-C¹⁴-6-α-H³的代谢
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The effect of cholesterol feeding on gallbladder bile acids of the rabbit. Evidence that lithocholic acid is a primary bile acid in the rabbit.胆固醇喂养对兔胆囊胆汁酸的影响。证明石胆酸是兔的一种初级胆汁酸。
Biochem J. 1981 Sep 15;198(3):639-43. doi: 10.1042/bj1980639.
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A comprehensive study of duodenal bile salts in newborn infants and their relationship to fat absorption.对新生儿十二指肠胆汁盐及其与脂肪吸收关系的综合研究。
Ir J Med Sci. 1980 Sep;149(9):346-56. doi: 10.1007/BF02939169.
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[Atypical bile acids (author's transl)].[非典型胆汁酸（作者译）]
Klin Wochenschr. 1980 Jan 15;58(2):55-63. doi: 10.1007/BF01477189.
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Lithocholate glucuronide is a cholestatic agent.石胆酸葡萄糖醛酸苷是一种胆汁淤积剂。
J Clin Invest. 1984 Jun;73(6):1507-14. doi: 10.1172/JCI111356.
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Bile acid synthesis by long-term cultured cell line established from human hepatoblastoma.由人肝母细胞瘤建立的长期培养细胞系进行胆汁酸合成。
J Clin Invest. 1982 Nov;70(5):1128-30. doi: 10.1172/jci110701.
9
Comparative studies of bile salts. 16-Deoxymyxinol, a second bile alcohol from hagfish.胆汁盐的比较研究。16-脱氧粘醇，一种来自盲鳗的第二种胆汁醇。
Biochem J. 1969 May;112(5):763-5. doi: 10.1042/bj1120763.
10
Bile salts of germ-free domestic fowl and pigs.无菌家禽和猪的胆汁盐。
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J Biol Chem. 1965 Mar;240:1059-63.
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PRESENT STATUS OF RESEARCH ON CATABOLISM AND EXCRETION OF CHOLESTEROL.胆固醇分解代谢与排泄的研究现状
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THIN-LAYER CHROMATOGRAPHY OF STEROLS AND STEROIDS.甾醇和类固醇的薄层色谱法
J Lipid Res. 1963 Jan;4:100-1.
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BILE ACIDS. XIX. METABOLISM OF LITHOCHOLIC ACID-24-14C IN THE RAT.胆汁酸。十九。大鼠体内石胆酸 -24 -¹⁴C的代谢
J Biol Chem. 1964 Jan;239:102-5.
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[Thin layer chromatography of phosphatides and glycolipids].[磷脂和糖脂的薄层色谱法]
Biochem Z. 1961;334:175-84.
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J Biol Chem. 1959 Feb;234(2):276-81.
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Bile acids. VII. Structure of acid I.胆汁酸。VII. 酸I的结构。
J Biol Chem. 1958 Feb;230(2):573-80.
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Bile acids. VI. The structure and synthesis of acid II.胆汁酸。VI. 酸II的结构与合成。
J Biol Chem. 1957 Jun;226(2):667-71.