肾脏磷酸烯醇丙酮酸羧激酶。亚细胞分布及对酸碱变化的反应
Phosphoenolpyruvate carboxykinase of kidney. Subcellular distribution and response to acid-base changes.
作者信息
Flores H, Alleyne G A
出版信息
Biochem J. 1971 Jun;123(1):35-9. doi: 10.1042/bj1230035.
Abstract
- A method for the assay of phosphoenolpyruvate carboxykinase is presented, based on the enzymic determination of the phosphoenolpyruvate produced by the enzyme reaction. 2. The subcellular distribution of phosphoenolpyruvate carboxykinase in the kidney of several animal species resembled the distribution in the liver. 3. The rise in enzyme activity in the kidney cortex of rats made acidotic by feeding with ammonium chloride was not prevented by administration of ethionine or actinomycin. 4. The possibility is suggested that in the kidney acidosis causes activation of an inactive form of the enzyme already present.
摘要
- 本文介绍了一种基于酶促测定酶反应产生的磷酸烯醇丙酮酸来测定磷酸烯醇丙酮酸羧激酶的方法。2. 几种动物肾脏中磷酸烯醇丙酮酸羧激酶的亚细胞分布与肝脏中的分布相似。3. 通过喂食氯化铵使大鼠发生酸中毒时，其肾皮质中酶活性的升高不受乙硫氨酸或放线菌素的影响。4. 这表明在肾脏中，酸中毒可能导致已存在的无活性形式的酶被激活。
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Phosphoenolpyruvate carboxykinase of kidney. Subcellular distribution and response to acid-base changes.肾脏磷酸烯醇丙酮酸羧激酶。亚细胞分布及对酸碱变化的反应
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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METABOLIC AND HORMONAL CONTROL OF PHOSPHOENOLPYRUVATE CARBOXYKINASE AND MALIC ENZYME IN RAT LIVER.大鼠肝脏中磷酸烯醇丙酮酸羧激酶和苹果酸酶的代谢与激素调控
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Mammalian liver phosphoneolpyruvate carboxykinase activities.哺乳动物肝脏磷酸烯醇丙酮酸羧激酶活性。
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Relation of renal gluconeogenesis to ammonia production in the dog and rat.犬和大鼠肾糖异生作用与氨生成的关系。
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Renal gluconeogenesis in acidosis, alkalosis, and potassium deficiency: its possible role in regulation of renal ammonia production.酸中毒、碱中毒和钾缺乏时的肾糖异生：其在调节肾氨生成中的可能作用。
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Nature. 1968 Mar 2;217(5131):847-8. doi: 10.1038/217847a0.
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