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对乙酰氨基酚存在下对氨基苯酚的荧光及测定

p-Aminophenol fluorescence and determination in the presence of acetaminophen.

作者信息

Street K W, Schenk G H

出版信息

J Pharm Sci. 1979 Oct;68(10):1306-9. doi: 10.1002/jps.2600681029.

DOI:10.1002/jps.2600681029
PMID:512867
Abstract

The spectrophotometric and fluorometric properties of the aminophenols and of several compounds related to p-aminophenol were examined. A direct spectrofluorometric method for p-aminophenol determination at trace levels in methanol was developed and evaluated for the effect of inner filtering by acetaminophen. The method was applied to the determination of p-aminophenol as an impurity in acetaminophen and acetaminophen-containing tablets.

摘要

对氨基酚以及几种与对氨基苯酚相关的化合物的分光光度和荧光特性进行了研究。开发了一种直接分光荧光法,用于测定甲醇中痕量水平的对氨基苯酚,并评估了对乙酰氨基酚的内滤效应。该方法应用于测定对乙酰氨基酚及含对乙酰氨基酚片剂中作为杂质的对氨基苯酚。

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