p-Aminophenol fluorescence and determination in the presence of acetaminophen.

The spectrophotometric and fluorometric properties of the aminophenols and of several compounds related to p-aminophenol were examined. A direct spectrofluorometric method for p-aminophenol determination at trace levels in methanol was developed and evaluated for the effect of inner filtering by acetaminophen. The method was applied to the determination of p-aminophenol as an impurity in acetaminophen and acetaminophen-containing tablets.