具有潜在抗血吸虫活性的新型巯基三唑的合成。
Synthesis of new mercaptotriazoles with potential antibilharzial activity.
作者信息
Soliman R, Hammouda N A
出版信息
J Pharm Sci. 1979 Nov;68(11):1377-81. doi: 10.1002/jps.2600681110.
PMID:512883
Abstract
Several 3-mercaptotriazoles with the 8-hydroxyquinoline moiety in the 5-position were prepared and tested for antiparasitic activity. Preliminary biological tests on experimentally infected mice with Schistosoma mansoni worms revealed that the new compounds possess potent schistosomicidal activity.
摘要
制备了几种在5位带有8-羟基喹啉部分的3-巯基三唑，并测试了其抗寄生虫活性。对曼氏血吸虫实验感染小鼠的初步生物学测试表明，这些新化合物具有强大的杀血吸虫活性。
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