麻疹病毒在悬浮培养物中的高效增殖
Efficient propagation of measles virus in suspension cultures.
作者信息
Baczko K, Lazzarini R A
出版信息
J Virol. 1979 Sep;31(3):854-5. doi: 10.1128/JVI.31.3.854-855.1979.
Abstract
Suspension cultures of a human prostate cell line (MA160) supported abundant growth of the Edmonston strain of measles virus. The virus yields obtained with these suspension cultures (150 to 800 PFU/cell) were at least 20- to 100-fold higher than those frequently reported in the literature. Monolayer cultures of MA160 cells did not support a virus replication nearly as efficiently (progeny yield, 25 PFU/cell).
摘要
人前列腺细胞系（MA160）的悬浮培养物支持麻疹病毒埃德蒙斯顿株大量生长。这些悬浮培养物获得的病毒产量（150至800个蚀斑形成单位/细胞）比文献中经常报道的产量至少高20至100倍。MA160细胞的单层培养物支持病毒复制的效率远不及此（子代产量为25个蚀斑形成单位/细胞）。
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本文引用的文献
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
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Structure and function relationships of the envelope of measles virus.麻疹病毒包膜的结构与功能关系
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Intracellular synthesis of measles virus-specified polypeptides.麻疹病毒特异性多肽的细胞内合成。
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