Shinozaki T, Sawai M, Fujii R
Jpn J Antibiot. 1979 Oct;32(10):1036-43.
Clinical studies on cefamandole were carried out with the following results. (1) Cefamandole was administered 100 mg/kg/day (q.i.d.) by intravenous route to 29 cases of children. In 10 out of 29 cases bacteriological effect was observed. Bacteriological response was effective in 8 cases (80.0%). Clinical responses were effective in 27 cases (93.1%). (2) As to adverse reactions, granulocytopenia and elevation of S-GOT, S-GPT developed in each two cases.
对头孢孟多进行了临床研究,结果如下。(1)对29例儿童按每日100mg/kg(分4次给药)静脉注射头孢孟多。29例中有10例观察到细菌学疗效。细菌学反应有效8例(80.0%)。临床反应有效27例(93.1%)。(2)关于不良反应,有2例出现粒细胞减少,2例出现血清谷草转氨酶(S-GOT)和血清谷丙转氨酶(S-GPT)升高。